Institute of Molecular Psychiatry

  • Director: Prof. Dr. rer. nat. Andreas Zimmer
  • University of Bonn
  • Venusberg-Campus 1, Bldg. 76
  • 53127 Bonn

Publications 1991-1999


Steiner H, Bonner T, Zimmer AM, Kitai ST, Zimmer A. (1999). Altered gene expression in striatal projection neurons in CB1 cannabinoid receptor knockout mice. Proc. Natl. Acad. Sci. USA, 96: 5786-5790.

Zimmer A, Zimmer AM, Hohman A, Herkenham M, Bonner T. (1999). Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proc Natl. Acad. Sci. USA, 96: 5780-5785.

Inoue M, Shimohira I, Yoshida A, Zimmer A, Mantyh P, Takeshima H, Sakurada T, Ueda H. (1999). Dose-related opposite modulation by nociceptin/orphanin FQ of substance P nociception in the nociceptors and spinal cord. J. Pharmacol. Exp. Ther., 291: 308-313.

Brady LS, Herkenham M., Rothman RB, Partilla JS, König M., Zimmer AM, Zimmer A. (1999). Region-specific up-regulation of opioid receptor binding in enkephalin knockout mice. Brain Res. Mol. Brain Res., 68: 193-197.

Hook S, Camberis M, Prout M, Konig M, Zimmer A, Heeke GV, Gros GL. (1999). Preproenkephalin is a Th2 cytokine but is not required for Th2 differentiation in vitro. Immunol. Cell Biol., 77: 385-390.

Jarai Z, Wagner JA, Varga K, Lake KD, Compton DR, Martin BR, Zimmer AM, Bonner TI, Buckley NE, Mezey E, Razdan RK, Zimmer A, Kunos G. (1999). Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 and CB2 receptors. Proc. Natl. Acad. Sci. USA, 96: 14136-14141.

Hahn H, Wojnowski L, Miller G, Zimmer A. (1999). The patched signaling pathway in tumorigenesis and development: lessons from animal models. J. Mol. Med., 77: 459-468.


Young WS, 3rd, Shepard E, DeVries AC, Zimmer A, LaMarca ME, Ginns EI, Amico J, Nelson RJ, Hennighausen L, Wagner KU. (1998). Targeted reduction of oxytocin expression provides insights into its physiological roles. Adv. Exp. Med. Biol., 449: 231-40.

Wojnowski L., Bernal R., Park C.M., Handel M.A., Hollander W.F., Zimmer A. (1998) Reduced activity of Braf protein kinase in hop and hop(hpy) mouse mutants. Mamm. Genome, 9: 905-906.

Wojnowski L, Stancato LF Zimmer AM, Beck TW, Larner AC, Rapp UR, Zimmer A. (1998). Craf-1 kinase is essentiell for mouse development. Mech. Dev., 76: 141-149.

Zimmer A, Zimmer AM, Baffi J, Reynolds K, Usdin T, Palkovits M, Mezey E. (1998). Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene. Proc. Natl. Acad. Sci. USA, 95: 2630-2635.

Inoue M, Tokuyama S, Shimohira I, Yoshida A, Kobayashi M, Kozaki S, Zimmer A, Ueda H. (1998). Nociceptin/orphanin FQ-induced nociceptive responses through substance P release from peripheral nerve endings in mice. Proc. Natl. Acad. Sci. USA, 95: 10949-10953.

Josephson R, Müller T, Pickel J, Okabe S, Reynolds K, Turner PA, Zimmer A, McKay RDG. (1998). POU transcription factors control expression of CNS stem cell specific genes. Development, 125: 3087-3100.


Bhattacharyya N., Dey A., Minucci S., Zimmer A., John S., Hager G., Ozato K. (1997). Retinoid-induced chromatin structure alterations in the retinoic acid receptor beta 2 promoter. Mol. Cell Biol. 17:6481-6490.

Wojnowski L, Zimmer A. (1997). Use of transgenic mice to study the activation of retionic acid-responsive promoters. Meth. Enzymol, 282: 77-85.

Wojnowski L, Zimmer AM, Beck TW, Hahn H, Bernal R, Rapp UR, Zimmer A. (1997). Endothelial apoptosis in Braf-deficient mice. Nature Genetics, 16: 293-297.

Hahn H, Wojnowski L, Zimmer AM, Hall J, Miller G. Zimmer A. (1998). Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome. Nature Medicine, 4: 619-622.


Hellmich HL, Kos L, Cho ES, Mahon KA, Zimmer A. (1996). Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions. Mech. Dev., 54: 95-105.

Robinson GW, Smith GS, Gallahan D, Zimmer A, Furth PA, Hennighausen L. (1996). Understanding mammary gland development through the imbalanced expression of growth regulators. Dev. Dyn., 206: 159-168.

Reynolds K, Zimmer AM, Zimmer A. (1996). Regulation of RAR beta 2 mRNA expression: Evidence for an inhibitory peptide encoded in the 5'-untranslated region. J Cell Biol., 134: 827-835.

König M, Zimmer AM, Steiner H, Holmes PV, Crawley JN, Brownstein MJ, Zimmer A. (1996). Pain responses, anxiety, and aggression in mice deficient in pre-proenkephalin. Nature, 383: 535-538.

Zimmer A. (1996). Gene targeting and behavior: a genetic problem requires a genetic solution. Trends Neurosci., 19: 470.


Kurtz A, Zimmer A. (1995). The mouse homolog of the human Miller-Dieker chromosomal region (MDCR) maps to mouse chromosome-11 in close proximity to Mov9 and D11Nds1. Mamm. Genome, 6: 145-146.

Kurtz A, Zimmer A. (1995). Interspecies fluorescence in-situ hybridization further defines synteny homology between mouse Chromosome-11 and human Chromosome-17. Mamm. Genome, 379-380.


Zimmer A, Zimmer A, Reynolds K. (1994). Gene targeting constructs: effects of vector topology on co-expression efficiency of positive and negative selectable marker genes. Biochem. Biophys. Res. Commun., 201: 943-949.

Zimmer A, Zimmer AM, Reynolds K. (1994). Tissue specific expression of the retinoic acid receptor-beta-2: Regulation by short open reading frames in the 5'-noncoding region. J. Cell Biol., 127: 1111-1119.

Kurtz A, Zimmer A, Schnütgen F, Brüning G, Spener F, Müller T. (1994). The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development. Development, 120: 2637-2649.

Eisel U, Reynolds K, Riddick M, Zimmer A, Zimmer A. (1994). Inhibition of Spermatogenesis by Tetanus Toxin Expression in Sertoli Cells of Transgenic Mice. In: Function of Somatic Cells in the Testis. (ed. A Bartke), pp 195-201. Springer-Verlag, New York.


Eisel U, Reynolds K, Riddick M, Zimmer A, Niemann H, Zimmer A. (1993). Tetanus toxin light chain expression in Sertoli cells of transgenic mice causes alterations of the actin cytoskeleton and disrupts spermatogenesis. EMBO J, 12: 3365-72.


Zimmer A, Zimmer A. (1992). Induction of a RAR beta 2-lacZ transgene by retinoic acid reflects the neuromeric organization of the central nervous system. Development, 116: 977-983.

Zimmer A. (1992). Manipulating the genome by homologous recombination in embryonic stem cells. Annu. Rev. Neurosci., 15: 115-37.

Zimmer A, Wang Z-Q, Wagner EF, Gruss P. (1992). Homologous recombination in embryonic stem cells as a means to generate mice with defined mutations. In: Mechanisms of Eucaryotic DNA Recombination. (ed. ME Gottesman, H Vogel), pp 29 - 40. Academic Press Inc., San Diego.


Reynolds K, Mezey E, Zimmer A. (1991). Activity of the beta-retinoic acid receptor promoter in transgenic mice. Mech. Dev., 36: 15-29.

Zimmer A, Gruss P. (1991). Use of polymerase chain reaction (PCR) to detect homologous recombination in transfected cell lines. In: Gene Transfer and Expression Protocols. Vol. 7 (ed. EJ Murray), pp 411-417. The Humana Press Inc., Clifton, NJ.