Institute of Molecular Psychiatry

  • Director: Prof. Dr. rer. nat. Andreas Zimmer
  • University of Bonn
  • Sigmund Freud Str. 25
  • 53127 Bonn

Publications 2000-2009

2009

Akhmetshina A, Dees C, Busch N, Beer J, Zimmer A, Distler O, Schett G, Distler JHW. (2009). The cannabinoid receptor CB2 exerts anti-fibrotic effects in experimental dermal fibrosis. Arth. Rheum., 60:1129-1136.

Glassmann A, Topka S, Wang-Eckardt L, Anders S, Weisheit G, Zimmer A, Schilling K. (2009). Basic molecular fingerprinting of immature cerebellar cortival inhibitory interneurons and their precursors. Neuroscience, 159: 69-82.

Otte DM, Bilkei-Gorzó A, Filiou MD, Turck CW, Yilmaz Ö, Holst MI, Schilling K, Abou-Jamra R, Schumacher J, Benzel I, Kunz WS, Beck H, Zimmer A. (2009). Behavioral changes in G72/G30 transgenic mice. Eur. Neuropsychopharm., 19: 339-348.

Defer N, Wan J, Souktani R, Escoubet B, Perier M, Caramelle P, Manin S, Deveaux V, Bourin MC, Zimmer A, Lotersztajn S, Pecker F, Pavoine C. (2009). The cannabinoid receptor type 2 promotes cardiac myocyte and fibroblast survival and protects against ischemia/reperfusion-induced cardiomyopathy. FASEB J., 23: 2120-2130.

Enard W, Gehre S, Hammerschmidt K, Hölter SM, Blass T, Somel M, Bruckner MK, Schreiweis C, Winter C, Sohr R, Becker L, Wiebe V, Nickel B, Giger T, Muller U, Groszer M, Adler T, Aguilar A, Bolle I, Calzada-Wack J, Dalke C, Ehrhardt N, Favor J, Fuchs H, Gailus-Durner V, Hans W, Hölzlwimmer G, Javaheri A, Kalaydjiev S, Kallnik M, Kling E, Kunder S, Moßbrugger I, Naton B, Racz I, Rathkolb B, Rozman J, Schrewe8 A, Busch DH, Graw J, Ivandic B, Klingenspor M, Klopstock T, Ollert M, Quintanilla-Martinez L, Schulz H, Wolf E, Wurst W, Zimmer A, Fisher SE, Morgenstern R, Arendt T, Hrabé de Angelis M, Fischer J, Schwarz J, Pääbo S. (2009). A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell, 137: 961-971.

Darvas M, Morsch M, Racz I, Ahmadi S, Swandulla D, Zimmer A. (2009). Modulation of the Ca2+ Conductance of Nicotinic Acetylcholine Receptors by Lypd6. Europ. Neuropsychopharm., 19: 670-681.

Nyilas R, Gregg LC, Mackie K, Watanabe M, Zimmer A, Hohmann AG and Katona I. (2009). Molecular architecture of endocannabinoid signaling at nociceptive synapses mediating analgesia. Eur. J. Neurosci., 29: 1964-1978.

Trigo JM, Zimmer A, Maldonado R. (2009). Nicotine anxiogenic and rewarding effects are decreased in mice lacking ß-endorphin. Neuropharmacology, 56: 1147-1153.

Deveaux V, Cadoudal T, Ichigotani Y, Teixeira-Clerc F, Louvet A, Manin S, Nhieu JT, Belot MP, Zimmer A, Even P, Cani PD, Knauf C, Burcelin R, Bertola A, Le Marchand-Brustel Y, Gual P, Mallat A, Lotersztajn S. (2009). Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis. PLoS ONE. 2009 Jun 9;4(6):e5844.

Karsak M, Malkin I, Toliat MR, Kubisch C, Nürnberg P, Zimmer A, Livshits G. (2009). The cannabinoid receptor type 2 (CNR2) gene is associated with hand bone strength phenotypes in an ethnically homogeneous family sample. Hum. Genet., 126(5): 629-36.

Wirth EK, Roth S, Blechschmidt C, Holter SM, Becker L, Racz I, Zimmer A, Klopstock T, Gailus-Durner V, Fuchs H, Wurst W, Naumann T, Brauer A, de Angelis MH, Kohrle J, Gruters A, Schweizer U. (2009). Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome. J. Neurosci., 29:9439-9449.

Crombag HS, Johnson AW, Zimmer AM, Zimmer A, Holland PC. (2009). Deficits in sensory-specific devaluation task performance following genetic deletions of cannabinoid (CB1) receptor. Learn Mem., 17(1):18-22.

Fuchs H, Gailus-Durner V, Adler T, Pimentel JA, Becker L, Bolle I, Brielmeier M, Calzada-Wack J, Dalke C, Ehrhardt N, Fasnacht N, Ferwagner B, Frischmann U, Hans W, Holter SM, Holzlwimmer G, Horsch M, Javaheri A, Kallnik M, Kling E, Lengger C, Maier H, Mossbrugger I, Morth C, Naton B, Noth U, Pasche B, Prehn C, Przemeck G, Puk O, Racz I, Rathkolb B, Rozman J, Schable K, Schreiner R, Schrewe A, Sina C, Steinkamp R, Thiele F, Willershauser M, Zeh R, Adamski J, Busch DH, Beckers J, Behrendt H, Daniel H, Esposito I, Favor J, Graw J, Heldmaier G, Hofler H, Ivandic B, Katus H, Klingenspor M, Klopstock T, Lengeling A, Mempel M, Muller W, Neschen S, Ollert M, Quintanilla-Martinez L, Rosenstiel P, Schmidt J, Schreiber S, Schughart K, Schulz H, Wolf E, Wurst W, Zimmer A, Hrabe de Angelis M. (2009) The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models. Curr. Pharm. Biotechno. 10:236-243.

Bab I, Zimmer A, Melamed E. (2009). Cannabinoids and the skeleton: From marijuana to reversal of bone loss. Ann. Med., 41(8):560-7.

Drews E, Zimmer A. (2009). Central sensitization needs sigma receptors. Pain, 145:269-270.

Klotz L, Burgdorf S, Dani I, Saijo K, Flossdorf J, Hucke S, Alferink J, Novak N, Beyer M, Mayer G, Langhans B, Klockgether T, Waisman A, Eberl G, Schultze J, Famulok M, Kolanus W, Glass C, Kurts C, Knolle PA. (2009). The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity. J Exp Med., 206(10):2079-89.

Haenisch B, Bilkei-Gorzó A, Caron MG, Bönisch H. (2009) Knockout of the norepinephrine transporter and pharmacologically diverse antidepressants prevent behavioral and brain neurotrophin alterations in two chronic stress models of depression. J. Neurochem, 111(2):403-416.

Kölsch H, Wagner M, Bilkei-Gorzó A, Toliat MR, Pentzek M, Fuchs A, Kaduszkiewicz H, van den Bussche H, Riedel-Heller SG, Angermeyer MC, Weyerer S, Werle J, Bickel H, Mösch E, Wiese B, Daerr M, Jessen F, Maier W, Dichgans M. Gene polymorphisms in prodynorphin (PDYN) are associated with episodic memory in the elderly. J Neural Transm, 2009, 116(7):897-903.

2008

Nenicu A, Luers GH, Kovacs W, Otte D, Zimmer A, Bergmann M, Baumgart-Vogt E. (2008). Peroxisomes in human and mouse testis: Differential expression of peroxisomal proteins in germ cells and distinct somatic cell types of the testis. Biol. Reprod. 77: 1060-1072.

Mátyás F, Urbán GM, Watanabe M, Mackie K, Zimmer A, Freund TF, Katona I. (2008). Identification of the sites of 2-arachidonoylglycerol synthesis and action imply retrograde endocannabinoid signaling at both GABAergic and glutamatergic synapses in the ventral tegmental area. Neuropharmacology, 54: 95-107.

Tam J, Trembovler V, Di Marzo V, Petrosino S, Leo G, Alexandrovich A, Regev E, Casap N, Shteyer A, Ledent C, Karsak M, Zimmer A, Mechoulam R, Yirmiya R, Shohami E, Bab I (2008). The Cannabinoid CB1 Receptor Regulates Bone Formation by Modulating Adrenergic Signaling. FASEB J., 22: 285-294.

Bilkei-Gorzo A, Racz I, Michel K, Darvas M, Maldonado R, Zimmer A. (2008). A common genetic predisposition to stress-sensitivity and stress-induced nicotine craving. Biol. Psychiatry, 63: 164-171. Epub Jun 13, 2007.

Bilkei-Gorzo A, Otto M, Zimmer A. (2008). Environmental modulation of anxiety-related neuronal activity and behaviours. Behav. Brain Res., 186: 289-292.

Noble F, Benturquia N, Bilkei-Gorzo A, Zimmer A, Roques BP. (2008). Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours. Psychopharmacology, 196: 327-335. Epub Oct 1, 2007.

Jones S, Tucker KL, Sage T, Kaiser WJ, Barrett NE, Lowry PJ, Zimmer A, Hunt SP, Emerson M, Gibbins JM. (2008). Peripheral tachykinins and the neurokinin receoptor NK1 are required for platelet thrombus formation. Blood, 111: 605-612. Epub Sept 25, 2007.

Suarez J, Bermudez-Silva FJ, Mackie K, Ledent C, Zimmer A, Cravatt BF, de Fonseca FR. (2008). Immunohistochemical description of the endogenous cannabinoid system in the rat cerebellum and functionally related nuclei. J. Comp. Neurol., 509: 400-421.

Bilkei-Gorzo A, Racz I, Michel K, Mauer D, Zimmer AM, Klingmuller D, Zimmer A. (2008). Control of hormonal stress reactivity by the endogenous opioid system. Psychoneuroendocrinology, 33: 425-436.

Bilkei-Gorzo A, Abo-Salem OM, Hayallah AM, Michel K, Muller CE, Zimmer A. (2008). Adenosine receptor subtype-selective antagonists in inflammation and hyperalgesia. Naunyn-Schmiedeberg's Arch. Pharmacol., 377: 65-76.

Gertsch J, Leonti M, Raduner S, Racz I, Chen JZ, Xie XQ, Altmann KH, Karsak M, Zimmer A. (2008). Beta-carophyllene is a diatary cannabinoid. Proc. Natl. Acad. Sci. USA, 26: 9099-9104.

Racz I, Schurmann B, Karpushova A, Reuter M, Cichon S, Montag C, Furst R, Schuetz C, Franke PE, Strohmaier J, Wienker TF, Terenius L, Osby U, Gunnar A, Maier W, Bilkei-Gorzo A, Nothen M, Zimmer A. (2008). The opioid peptides enkephalin and beta-endorphin in alcohol dependence. Biol. Psychiatry, 64: 989-997.

Racz I, Bilkei-Gorzo A, Markert A, Stamer F, Gothert M, Zimmer A. (2008) Anandamide effects on 5-HT3 receptors in vivo. Europ. J. Pharmacol., 596: 98-101.

Grote A, Boldogkoi Z, Hans M, Zimmer A, Steinhauser C., Jabs R. (2008). Nanomolar ambient ATP decelerates P2X3 receptor kinetics. Neuropharmacology, 55: 1212-1218.

Paldy E, Bereczki E, Santha M, Wenger T, Borsodi A, Zimmer A, Benyhi, S. (2008) CB2 cannabinoid receptor antagonist SR144528 decreases mu-opioid receptor expression and activation in mouse brainstem: role of CB2 receptor in pain. Neurochem. Int., 53: 309-316.

Galeote L, Berrendero F, Bura SA, Zimmer A, Maldonado R. (2008) Prodynorphin gene disruption increases the sensitivity to nicotine self-administration in mice. Int. J. Neuropsychoph., 12:615-625.

Racz I, Nadal X, Alferink J, Banos JE, Rehnelt J, Martin M, Pintado B, Gutierrez-Adan A, Sanguino E, Manzanares J, Zimmer A#, Maldonado R. (2008). Crucial role of CB2 cannabinoid receptor in the regulation of central immune responses during neuropathic pain. J.Neurosci., 28: 12125-12135. #corresponding author.

Racz I, Nadal X, Alferink J, Banos JE, Rehnelt J, Martin JM, Pintado B, Gutierrez-Adan A, Sanguino E, Manzanares J, Bellora N, Zimmer A#, Maldonado R. (2008). Interferon-gamma is a critical modulator of CB2 cannabinoid receptor signaling during neuropathic pain. J.Neurosci., 28: 12136-12145. #corresponding author.

Avraham Y, Zolotarev O, Grigoriadis NC, Pautahidis T, Magen I, Vorobiav L, Zimmer A, Ilan Y, Mechoulam R, Berry E M. (2008) Cannabinoids and capsaicin improve liver function following thioacetamide-induced acute injury in mice. Am J Gastroenterol, 103, 3047-56.

Karsak M, Bab I, Zimmer A. (2008). New insights into the endocannabinoid system by using cannabinoid receptor knockout mice. In: The Cannabinoid Receptors. (ed. P. Reggio), Humana Press.

Lotersztajn S, Teixeira-Clerc F, Julien B, Deveaux V, Ichigotani Y, Manin S, Tran-Van-Nhieu J, Karzak M, Zimmer A, Mallat A. (2008). CB2 receptors as new therapeutic targets during liver diseases. Br. J. Pharm., 153: 286-289.

Bab I, Ofek O, Tam J, Rehnelt J, Zimmer A. (2008). Endocannabinoids and the regulation of bone metabolism. J. Neuroendocrinol., Suppl. 1: 69-74.

Drews E, Becker A, Bilkei-Gorzo A, Zimmer A. (2008) Animal models of affective behaviors and drug addiction. In:Biomarkers for Psychiatric Disorders. (ed. C.W. Turck). 217-234.

2007

Bilkei-Gorzo A, Michel K, Noble F, Roques BP, Zimmer A. (2007). Preproenkephalin knockout mice show no depression-related phenotype. Neuropsychopharmacology, 32: 2330-2337.

Bailey A, Yoo JH, Rácz I, Zimmer A, Kitchen I. (2007). Preprodynorphin mediates locomotion and D2 dopamine and mu- opioid receptor changes induced by chronic “binge” cocaine administration. J. Neurochem, 102: 1817-1830.

Karsak M, Gaffal E, Date R, Wang-Eckhardt L, Rehnelt J, Petrosino S, Starowicz K, Steuder R, Schlicker E, Cravatt B, Mechoulam R, Buettner R, Werner S, Di Marzo V, Tuting T, Zimmer A. (2007). Attenuation of allergic contact dermatitis through the endocannabinoid system. Science, 316: 1494-1497.

Mazzuca M, Heurteaux C, Alloui A, Diochot S, Baron A, Voilley N, Blondeau N, Gélot A, Cupo A, Zimmer A, Zimmer AM, Eschalier A, Lazdunski M. (2007). A tarantula peptide against pain via ASIC1a channels and opioid mechanisms. Nat. Neurosci., 10: 943-945.

Bab I, Zimmer A. (2007). Cannabinoid receptors and the regulation of bone mass. Br. J. Pharm., 153: 182-188.

Schürmann B, Rácz I, Zimmer A. (2007). Tierexperimentelle Untersuchungen zur Funktion des endogenen Opioidsystems bei der Modulation von Suchtverhalten. Nervenheilkunde. 26: 897-901.

Karsak M, Zimmer A. (2007). Cannabinoide im Einsatz bei Allergien. BIOforum, 5: 52-53.

Berner J, Shvarev Y, Lagercrantz H, Bilkei-Gorzo A, Hškfelt T, Wickstršm R (2007). Altered respiratory pattern and hypoxic response in transgenic newborn mice lacking the tachykinin-1 gene. J.Appl.Physiol., 103 (2): 552-559

2006

Mendizábal V, Zimmer A, Maldonado R. (2006). Involvement of kappa/dynorphin system in WIN 55,212-2 self-administration in mice. Neuropharmacology, 31: 1957-1966.

Duarte C, Schütz B, Zimmer A. (2006). Incongruent pattern of neurokinin B expression in rat and mouse brains. Cell Tiss. Res., 323: 43-51.

Ofek O, Karsak M, Leclerc N, Fogel M, Frenkel B, Wright K, Tam J, Attar-Namdar M, Kram V, Shohami E, Mechoulam R, Zimmer A, Bab I. (2006). Peripheral CB2 Cannabinoid Receptor, CB2, Regulates Bone Mass. Proc. Natl. Acad. Sci. USA, 103: 696-701.

Heneka MT, Ramanathan M, Jacobs AH, Dumitrescu-Ozimek L, Bilkei-Gorzo A, Debeir T, Sastre M, Galldiks N, Zimmer A, Hoehn M, Heiss WD, Klockgether T, Staufenbiel M (2006) Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice. J Neurosci. 26:1343-1354.

Tam J, Ofek O, Friede E, Ledent C, Gabet Y, Muller R, Zimmer A, Mackie K, Mechoulam R, Shohami E, Bab I. (2006). Involvement of neuronal cannabinoid receptor CB1 in regulation of bone mass and bone remodeling. Mol. Pharmacol., 70: 786-792.

Racz I, Zimmer A. (2006) Animal models in nociception. In: Standards of Mouse Phenotyping (ed. Hrabé de Angelis, Chambon, Brown).

2005

Berrendero F, Mendizábal V, Robledo P, Galeote L, Bilkei-Gorzo A, Zimmer A, Maldonado R (2005). Nicotine-induced antinociception, rewarding effects, and physical dependence are decreased in mice lacking the preproenkephalin gene. J.Neurosci., 25: 1103-1112.

Julien B, Grenard P, Teixeira-Clerc F, Van Nhieu JT, Li L, Karsak M, Zimmer A, Mallat A, Lotersztajn S. (2005). Antifibrogenic role of the cannabinoid receptor CB2 in the liver. Gastroenterology, 128: 742-755.

Steffens S, Veillard NR, Arnaud C, Pelli G, Burger F, Staub C, Karsak M, Zimmer A, Frossard JL, Mach F. (2005). Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice. Nature 434: 782-786.

Gailus-Durner V, Fuchs H, Becker L, Bolle I, Brielmeier M, Calzada-Wack J, Elvert R, Ehrhardt N, Dalke C, Franz TJ, Grundner-Culemann E, Hammelbacher S, Hölter SM, Hölzlwimmer G, Horsch M, Javaheri A, Kalaydjiev S, Klempt M, Kling E, Kunder S, Lengger C, Lisse T, Mijalski T, Naton B, Pedersen V, Prehn C, Przemeck G, Racz I, Reinhard C, Reitmeir P, Schneider I, Schrewe A, Steinkamp R, Zybill C, Adamski J, Beckers J, Behrendt H, Favor J, Graw J, Heldmaier G, Höfler H, Ivandic B, Katus H, Kirchhof P, Klingenspor M, Klopstock T, Lengeling A, Müller W, Ohl F, Ollert M, Quintanilla-Martinez L, Schmidt J, Schulz H, Wolf E, Wurst W, Zimmer A, Busch DH, Hrabé de Angelis M. (2005). Introducing the German Mouse Clinic: Open access platform for standardized phenotyping. Nat. Methods, 2: 403-404.

Schütz B, Reimann J, Dumitrescu-Ozimek L., Schürmann B, Kappes-Horn K, Landreth GE, Zimmer A, Heneka MT. (2005). The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A tansgenic mice. J.Neurosci., 25: 7805-7812.

The FANTOM Consortium, Riken Genome Science Laboratory and Riken Genome Exploration Research Group. (FANTOM Consortium: Carninci P, Kasukawa T, Katayama S, Gough J, Frith M, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest ARR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen J, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Basal M, Beisel KW, Bersano T, Bono H, Bradt D, Chiu KP, Chalk A, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, McWilliam S, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Hallinan J, Harbers M, Harokopos V, Hatanaka K, Hayashi Y, Henning S, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SPT, Kruger A, Kummerfeld S, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Mohan M, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, van Nimwegene E, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Qi D, Qu W, Reed J, Reid J, Ring BZ, Ringwald M, Rost B, Ruan Y, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CAM, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann S, Ueda HR, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick J, Hume D; RIKEN Genome Exploration Research Group: Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori M, Suzuki M, Aoki J, Arakawa T, Hori F, Hirakiyama A, Iida J, Imamura K, Imotani K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Murakami K, Nakano K, Ninomiya N, Nishio T, Nishiyori H, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Tsujimura Y, Waki K, Watahiki A, Oho Y, Suzuki H, Kawai J, Hayashizaki Y. (2005). The transcriptional landscape of the mammalian genome. Science, 309: 1559-1563.

Bilkei-Gorzo A, Racz I, Valverde O, Otto M, Michel K, Sarstre M, Zimmer A. (2005). Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors. Proc. Natl. Acad. Sci. USA, 102: 15670-15675.

Karsak M, Cohen-Solal M, Freudenberg J, Ostertag A, Morieux C, Kornak U, Essig J, Erxlebe E, Bab I, Kubisch C, de Vernejoul MC, Zimmer A. (2005). Cannabinoid receptor type 2 gene is associated with human osteoporosis. Mol. Human Genet., 14: 3389-3396.

Guan JS, XU ZZ, Gao H, He SQ, Ma GQ, Sun T, Wang LH, Zhang ZN, Lena I, Kitchen I, Elde R, Zimmer A, He C, Pei G, Bao L, Zhang X. (2005). Interaction with vesicle luminal Protachykinin regulates surface expression of delta-opioid receptors and opioid analgesia. Cell 122: 619-631.

Rodd ZA, Anstrom KK, Knapp DJ, Racz I, Zimmer A, Serra S, Bell RL, Woodward DJ, Breese GR, Colombo G. (2005). Factors mediating alcohol craving and relapse: Stress, compulsivity, and genetics. Alcohol Clin. Exp. Res., 29: 1325-1333.

Grote A, Boldogkoi Z, Zimmer A, Steinhäuser C, Jabs R. (2005). Functional characterization of P2X(3) receptors fused with fluorescent proteins. Mol. Membrane Biol., 22: 497-506.

Racz I, Schütz B, Abo-Salem O, Zimmer A. (2005). Visceral, inflammatory and neuropathic pain in glycine receptor alpha 3-deficient mice. Neuroreport, 16: 2025-2028.

Valverde O, Karsak M, Zimmer A. (2005). Analysis of the endocannabinoid system by using CB1 cannabinoid receptor knockout mice. Handbook of Pharmacology, 168: 115-142.

Bilkei-Gorzo A, Zimmer A. (2005). Mutagenesis and knockout models: NK1 and substance P. Handbook of Pharmacology, 169: 143-162.

2004

Abo-Salem OM, Hayallah AM, Bilkei-Gorzo A, Filipek B, Zimmer A#, Müller CE. (2004). Anticociceptive effects of novel A2B adenosine receptor antagonists, JPET, 308: 358-366 #corresponding author.

Schütz B, Mauer D, Salmon AM, Changeux JP, Zimmer A. (2004). Analysis of the cellular expression pattern of beta-CGRP in alpha-CGRP-deficient mice. J. Comp. Neurol. 476: 32-43.

Pritchard C, Hayes L, Wojnowski L, Zimmer A, Marais R, Norman J (2004). B-raf acts via ROCKII/LIMK/cofilin pathway to maintain actin stress fibres in fibroblasts. MCB, 24: 5937-5952.

Bilkei-Gorzo A, Michel K, Zimmer AM, Klingmüller D, Zimmer A. (2004). Behavioral phenotype of pre-proenkephalin-deficient mice on diverse congenic backgrounds. Psychopharmacology, 176: 343-352.

Harvey RJ, Depner UB, Wässle H, Ahmadi S, Heindl C, Reinold H, Smart TG, Harvey K, Schütz B, Abo-Salem O, Zimmer A, Poisbeau P, Welzl H, Wolfer DP, Betz H, Zeilhofer HU, Müller U (2004). GlyR alpha 3: an Essential Target for Spinal PGE(2)-Mediated Inflammartory Pain Sensitization. Science, 304: 884-887.

Bailey A, Weber D, Zimmer A, Zimmer AM, Hourani SM, Kitchen I. (2004). Quantitative autoradiography of adenosine receptors and NBTI-sensitive adenosine transporters in the brains of mice deficient in the preproenkephalin gene. Brain Res., 1025: 1-9.

2003

Racz I, Bilkei-Gorzo A, Toth ZE, Michel K, Palkovits M, Zimmer A. (2003). A critical role for the cannabinoid CB1 receptors in alcohol dependence and stress-stimulated ethanol drinking. J. Neurosci., 23: 2453-2458.

Wang L, Liu J, Harvey-White J, Zimmer A, Kunos G. (2003). Endocannabinoid signaling via cannabinoid receptor is involved in ethanol preference and its age-dependent decline in mice. Proc. Natl. Acad. Sci. USA., 100: 1393-1398.

Gustincich S, Batalov S, Beisel KW, Bono H, Carninci P, Fletcher CF, Grimmond S, Hirokawa N, Jarvis ED, Jegla T, Kawasawa Y, LeMieux J, Miki H, Raviola E, Teasdale RD, Tominaga N, Yagi K, Zimmer A, Hayashizaki Y, Okazaki Y. (2003) Analysis of the mouse transcriptome for genes involved in the function of the nervous system. Genome Res 13: 1395-1401.

Clarke S, Zimmer A, Zimmer AM, Hill RG, Kitchen I (2003). Region selective up-regulation of the mu-, delta- and kappa-opioid receptor but not opioid receptor-like 1 receptors in the brains of enkephalin and dynorphin knockout mice. Neuroscience, 122: 479-489

Zimmer A. (2003). Maus-Genom entziffert. Biologie in unserer Zeit, 33(2): 78-79.

2002

Yoshida T, Hashimoto K, Zimmer A, Maejima T, Araishi K, Kano M. (2002). The Cannabinoid CB1 Receptor Mediates Retrograde Signals for Depolarization-Induced Suppression of Inhibition in Cerebellar Purkinje Cells. J. Neurosci., 22: 1690-1697.

Ohno-Shosaku T., Tsubokawa H., Mizushima I., Yoneda N., Zimmer A., Kano M. (2002). Presynaptic cannabinoid sensitivity is a major determinant of depolarization-induced retrograde suppression at hippocampal synapses. J. Neurosci., 22: 3864-3872.

Chen CC, Zimmer A., Sun WH, Hall J, Brownstein MJ, Zimmer A. (2002). A role for ASIC3 in the modulation of high-intensity pain stimuli. Proc. Natl. Acad. Sci. USA, 99: 8992-8997.

Boldogköi Z, Schütz B, Sallach J, Zimmer A. (2002) P2X(3) receptor expression at early stages of mouse embryogenesis. Mech. Dev., 118: 255-260.

Bilkei-Gorzo A, Radcz I, Zimmer A. (2002). Diminished Anxiety- and Depression-Related Behaviors in Mice with Selective Deletion of the Tac1 Gene. J. Neurosci., 22: 10046-10052.

The FANTOM Consortium* and The RIKEN Genome Exploration Research Group # (*Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schonbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A) (#Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y). (2002). Analysis of the Mouse Transcriptome based upon Functional Annotation of 60,770 full length cDNAs. Nature, 420: 563-573.

Karsak M, Hrabé de Angelis M., Zimmer A. (2002). Mausmutanten in der Schmerzforschung: Neue Erkenntnisse durch Genmutationen. Biospektrum, 1.02: 17-21

2001

Hopley RL, Zimmer A. (2001). MouseBank: A Database application for managing transgenic mouse breeding programs. BioTechniques, 30: 130-132.

Selley DE, Rorrer WK, Breivogel CS, Zimmer AM, Zimmer A, Martin B, Sim-Selley LJ. (2001). Agonist efficacy and receptor efficiency in heterozygous CB1 knockout mice: Relationship of reduced CB1 receptor density to G-protein activation. J. Neurochem. 77: 1048-1057.

Kathmann M, Weber B, Zimmer A, Schlicker E. (2001) Enhanced acetylcholine release in the hippocampus of cannabinoid CB1 receptor-deficient mice. Br. J. Pharm. 132: 1169-1173.

Paria BC, Song H, Wang X, Schmid PC, Krebsach RJ, Schmid HHO, Bonner TI, Zimmer A, Dey SK. (2001). Dysregulated cannabinoid signaling disrupts uterine receptivity for embryo implantation. J. Biol. Chem. 8: 276: 20523-20528.

Nadeau JH, Balling R, Barsh G, Beier D, Brown DM, Bucan M, Camper S, Carlson G, Copeland N, Eppig J, Fletcher C,Frankel W, Ganten D, Goldowitz D, Goodnow C, Guenet JL, Hicks G, Hrabe de Angelis M, Jackson I, Jenkins N, Johnson D, Justice M, Kay S, Kingsley D, Lehrach H, Magnuson T, Meisler M, Poustka AM, Rinchik G, Rossant J, Russell L, Schimenti J, Shiroishi T, Skarnes B, Soriano P, Stanford B, Takahashi J, Wurst W, Zimmer A (2001). Sequence interpretation - Functional annotation of mouse genome sequences. Science, 291: 1251-1255

Kingery WS, Sawamura S, Agashe GS, Davies MF, Clark JD, Zimmer A. (2001). Enkephalin release and opioid receptor activation does not mediate the antinociceptive or sedative/hypnotic effects of nitrous oxide. Eur. J. Pharm. 427: 27-35.

Zimmer A, Valjent E, König M, Zimmer AM, Clarke S, Robledo P, Chen CC, Hahn H, Valverde O, Hill RG, Kitchen I, Maldonado R. (2001). Absense of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice. J. Neurosci. 21: 9499-9505.

2000

Wojnowski L, Stancato LF, Larner AC, Rapp UR, Zimmer A. (2000). Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis. Mech. Dev., 91:97-104.

Járai Z, Wagner JA, Goparaju SK, Wang L, Razdan RK, Sugiura T, Zimmer AM, TI Bonner, Zimmer A, Kunos G. (2000). Cardiovascular effects of 2-arachidonyl glycerol in anesthetized mice. Hypertension, 35: 679-684.

Buckley NE, McCoy KL, Mezey E, Bonner T, Zimmer AM, Felder CC, Glass M, Zimmer A. (2000). Immunomodulation by Cannabinoids is Absent in Mice Deficient for the Cannabinoid CB2 Receptor. Europ. J. Pharmacol., 396: 141-149.

Hook S, Prout M, Camberis M, Konig M, Zimmer A, Van Heeke G, Le Gros G, (2000). Th2-dependent airway eosinophilia is regulated by preproenkephalin. J. Neuroimmunol 107: 59-65

Hahn H, Wojnowski L, Specht K, Kappler R, Calzada-Wack J, Potter D, Zimmer A, Muller U, Samson E, Quintanilla-Martinez L, and Zimmer A.. 2000. Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma. J. Biol. Chem., 37: 28341-28344.

Hrabe de Angelis MH, Flaswinkel H, Fuchs H, Rathkolb B, Soewarto D, Marschall S, Heffner S, Pargent W, Wuensch K, Jung M, Reis A, Richter T, Alessandrini F, Jakob T, Fuchs E, Kolb H, Kremmer E, Schaeble K, Rollinski B, Roscher A, Peters C, Meitinger T, Strom T, Steckler T, Holsboer F, Klopstock T, Gekeler F, Schindewolf C, Jung T, Avraham K, Behrendt H, Ring J, Zimmer A, Schughart K, Pfeffer K, Wolf E, Balling R. (2000) Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nature Genetics, 25: 444-447.

Di Marzo V, Breivogel CS, Tao Q, Bridgen DT, Razdan RK, Zimmer AM, Zimmer A, Martin BR. (2000). Levels, metabolism, and pharmacological activity of anandamide in CB1 cannabinoid receptor knockout mice: Evidence for non-CB1, non-CB2 receptor-mediated actions of anandamide in mouse brain. J. Neurochem., 75: 2434-2444.

Valverde O, Maldonado R, Valjent E, Zimmer AM, Zimmer A. (2000) Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knockout mice. J. Neurosci., 20: 9284-9289.

Zimmer A, Usdin T. (2000). Examination of the opioid system using targeted gene deletions. In: Molecular Basis of Pain Induction. (ed. J.N. Wood). Wiley-Liss. 193-207.