Institute of Molecular Psychiatry

  • Director: Prof. Dr. rer. nat. Andreas Zimmer
  • University of Bonn
  • Sigmund Freud Str. 25
  • 53127 Bonn

Publications 2011

Louvet A, Teixeira-Clerc F, Chobert MN, Deveaux V, Pavoine C, Zimmer A, Pecker F, Mallat A, Lotersztajn S. (2011). Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice. Hepatology, 54(4):1217-26.

Sigel E, Baur R, Rácz I, Marazzi J, Smart T, Zimmer A, Gertsch J. (2011). The major central endocannabinoid directly acts at GABAA receptors. Proc Natl Acad Sci U S A, 108(44):18150-5.

Jeub M, Emrich M, Pradier B, Taha O, Gailus-Durner V, Fuchs H, de Angelis MH, Huylebroeck D, Zimmer A, Beck H, Racz I. (2011). The transcription factor Smad-interacting protein 1 controls pain sensitivity via modulation of DRG neuron excitability. Pain, 152(10):2384-98.

Dastig S, Nenicu A, Otte DM, Zimmer A, Seitz J, Baumgart-Vogt E, Lüers GH. (2011). Germ cells of male mice express genes for peroxisomal metabolic pathways implicated in the regulation of spermatogenesis and the protection against oxidative stress. Histochem Cell Biol, 136(4):413-25.

Hoyer FF, Steinmetz M, Zimmer S, Becker A, Lütjohann D, Buchalla R, Zimmer A, Nickenig G. (2011). Atheroprotection via cannabinoid receptor-2 is mediated by circulating and vascular cells in vivo. J Mol Cell Cardiol, 51(6):1007-14.

Holl D, Kuckenberg P, Woynecki T, Egert A, Becker A, Huss S, Stabenow D, Zimmer A, Knolle P, Tolba R, Fischer HP, Schorle H. (2011). Transgenic overexpression of Tcfap2c/AP-2gamma results in liver failure and intestinal dysplasia. PLoS One, 6(7):e22034.

Albayram O, Alferink J, Pitsch J, Piyanova A, Neitzert K, Poppensieker K, Mauer D, Michel K, Legler A, Becker A, Monory K, Lutz B, Zimmer A, Bilkei-Gorzo A. (2011). Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging. Proc Natl Acad Sci U S A, 108(27):11256-61.

Trebicka J, Racz I, Siegmund SV, Cara E, Granzow M, Schierwagen R, Klein S, Wojtalla A, Hennenberg M, Huss S, Fischer HP, Heller J, Zimmer A, Sauerbruch T. (2011). Role of cannabinoid receptors in alcoholic hepatic injury: steatosis and fibrogenesis are increased in CB(2) receptor-deficient mice and decreased in CB(1) receptor knockouts. Liver Int., 31(6):862-72. doi: 10.1111/j.1478-3231.2011.02496.x.

Otte DM, Sommersberg B, Kudin A, Guerrero C, Albayram Ö, Filiou MD, Frisch P, Yilmaz Ö, Drews E, Turck CW, Bilkei-Gorzó A, Kunz WS, Beck H and Zimmer A. (2011). N-acetyl cysteine treatment rescues cognitive deficits induced by mitochondrial dysfunction in G72/G30 transgenic mice. Neuropsychopharmacology, 36(11):2233-43.

Braun A, Engel T, Aguilar-Pimentel JA, Zimmer A, Jakob T, Behrendt H, Mempel M. (2011). Beneficial effects of cannabinoids (CB) in a murine model of allergen-induced airway inflammation: Role of CB(1)/CB(2) receptors. Immunobiology, 15;412(2):134-40.

Cichon S, Mühleisen TW, Degenhardt FA, Mattheisen M, Miró X, Strohmaier J, Steffens M, Meesters C, Herms S, Weingarten M, Priebe L, Haenisch B, Alexander M, Vollmer J, Breuer R, Schmäl C, Tessmann P, Moebus S, Wichmann HE, Schreiber S, Müller-Myhsok B, Lucae S, Jamain S, Leboyer M, Bellivier F, Etain B, Henry C, Kahn JP, Heath S; Bipolar Disorder Genome Study (BiGS) Consortium, Hamshere M, O'Donovan MC, Owen MJ, Craddock N, Schwarz M, Vedder H, Kammerer-Ciernioch J, Reif A, Sasse J, Bauer M, Hautzinger M, Wright A, Mitchell PB, Schofield PR, Montgomery GW, Medland SE, Gordon SD, Martin NG, Gustafsson O, Andreassen O, Djurovic S, Sigurdsson E, Steinberg S, Stefansson H, Stefansson K, Kapur-Pojskic L, Oruc L, Rivas F, Mayoral F, Chuchalin A, Babadjanova G, Tiganov AS, Pantelejeva G, Abramova LI, Grigoroiu-Serbanescu M, Diaconu CC, Czerski PM, Hauser J, Zimmer A, Lathrop M, Schulze TG, Wienker TF, Schumacher J, Maier W, Propping P, Rietschel M, Nöthen MM. (2011). Genome-wide Association Study Identifies Genetic Variation in Neurocan as a Susceptibility Factor for Bipolar Disorder. Am J Hum Genet., 88(3):372-81.

Specht S*, Frank JK*, Alferink J, Dubben B, Layland LE, Denece G, Bain O, Förster I, Kirschning CJ, Martin C, Hoerauf A. (2011). CCL17 controls mast cells for the defense against filarial larval entry. J Immunol., 186(8):4845-52. *equal contribution

Schicho R, Bashashati M, Bawa M, McHugh D, Saur D, Hu HM, Zimmer A, Lutz B, Mackie K, Bradshaw HB, McCafferty DM, Sharkey KA, Storr M. (2011). The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment. Inflamm Bowel Dis, 17(8):1651-64.

Horsch M, Seeburg PH, Adler T, Aguilar-Pimentel JA, Becker L, Calzada-Wack J, Garrett L, Götz A, Hans W, Higuchi M, Hölter SM, Naton B, Prehn C, Puk O, Rácz I, Rathkolb B, Rozman J, Schrewe A, Adamski J, Busch DH, Esposito I, Graw J, Ivandic B, Klingenspor M, Klopstock T, Mempel M, Ollert M, Schulz H, Wolf E, Wurst W, Zimmer A, Gailus-Durner V, Fuchs H, de Angelis MH, Beckers J. (2011). Requirement of the RNA-editing Enzyme ADAR2 for Normal Physiology in Mice. J Biol Chem., 286(21):18614-22.

Kuckenberg P, Peitz M, Kubaczka C, Becker A, Egert A, Wardelmann E, Zimmer A, Brüstle O, Schorle H. (2011) Lineage Conversion of Murine Extraembryonic Trophoblast Stem Cells to Pluripotent Stem Cells. Mol Cell Biol., 31(8):1748-56.

Quinn JP, Kipar A, Hughes DJ, Bennett E, Cox H, McLaughlin L, Zimmer A, Hunt SP, StewartJP. (2011). Altered host response to murine gammaherpesvirus 68 infection in mice lacking the tachykinin 1 gene and the receptor for substance P. Neuropeptides, 45: 49-53.

Fuchs H, Durner VG, Adler T, Aguilar-Pimentel JA, Becker L, Calzada-Wack J, Da Silva-Buttkus P, Neff F, Götz A, Hans W, Hölter SM, Horsch M, Kastenmüller G, Kemter E, Lengger C, Maier H, Matloka M, Möller G, Naton B, Prehn C, Puk O, Rácz I, Rathkolb B, Römisch-Marg W, Rozman J, Wang-Sattler R, Schrewe A, Stöger C, Tost M, Adamski J, Aigner B, Beckers J, Behrendt H, Busch DH, Esposito I, Graw J, Illig T, Ivandic B, Klingenspor M, Klopstock T, Kremmer E, Mempe M, Neschen S, Ollert M, Schulz H, Suhre K, Wolf E, Wurst W, Zimmer A, de Angelis MH. (2011). Mouse Phenotyping. Methods: available online.

Kosel M, Bilkei-Gorzo A, Zawatzky R, Zimmer A, Schlaepfer TE. (2011). Pegylated human interferon alpha 2a does not induce depression-associated changes in mice. Psychiatry Res., 185(1-2):243-7.

Ofek O, Attar-Namdar M, Kram V, Dvir-Ginzberg M, Mechoulam R, Zimmer A, Frenkel B, Shohami E, Bab I. (2010). CB2 cannabinoid receptor targets mitogenic Gi protein - cyclin D1 axis in osteoblasts. J Bone Miner Res., 26(2):308-316.