Institute of Molecular Psychiatry

  • Director: Prof. Dr. rer. nat. Andreas Zimmer
  • University of Bonn
  • Sigmund Freud Str. 25
  • 53127 Bonn

Publications 2013

Hoyer FF, Khoury M, Slomka H, Kebschull M, Lerner R, Lutz B, Schott H, Lütjohann D, Wojtalla A, Becker A, Zimmer A, Nickenig G. (2013). Inhibition of endocannabinoid-degrading enzyme fatty acid amide hydrolase increases atherosclerotic plaque vulnerability in mice. J Mol Cell Cardiol, 66C:126-132.

Gennequin B, Otte DM, Zimmer A. (2013). CRISPR/Cas-induced double-strand breaks boost the frequency of gene replacements for humanizing the mouse Cnr2 gene. Biochem Biophys Res Commun., 441:815-819.

Neff F, Flores-Dominguez D, Ryan DP, Horsch M, Schröder S, Adler T, Afonso LC, Aguilar-Pimentel JA, Becker L, Garrett L, Hans W, Hettich MM, Holtmeier R, Hölter SM, Moreth K, Prehn C, Puk O, Rácz I, Rathkolb B, Rozman J, Naton B, Ordemann R, Adamski J, Beckers J, Bekeredjian R, Busch DH, Ehninger G, Graw J, Höfler H, Klingenspor M, Klopstock T, Ollert M, Stypmann J, Wolf E, Wurst W, Zimmer A, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Ehninger D. (2013). Rapamycin extends murine lifespan but has limited effects on aging. J. Clin. Invest., 123(8):3272-91.

Klauke AL, Racz I, Pradier B, Markert A, Zimmer AM, Gertsch J, Zimmer A. (2013). The cannabinoid CB2 receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic pain. Eur Neuropsychopharmacol, 24(4):608-20.

Wenzel D, Matthey M, Bindila L, Lerner R, Lutz B, Zimmer A, Fleischmann BK. (2013). Endocannabinoid anandamide mediates hypoxic pulmonary vasoconstriction. Proc Natl Acad Sci U S A. 110(46):18710-5.

Montani G, Tonelli S, Sanghez V, Ferrari PF, Palanza P, Zimmer A, Tirindelli R. (2013). Aggressive behaviour and physiological responses to pheromones are strongly impaired in mice deficient for the olfactory G-protein -subunit G8. J Physiol., 591:3949-62.

Heidt H, Cinar MU, Uddin MJ, Looft C, Jüngst H, Tesfaye D, Becker A, Zimmer A, Ponsuksili S, Wimmers K, Tholen E, Schellander K, Große-Brinkhaus C. (2013). A genetical genomics approach reveals new candidates and confirms known candidate genes for drip loss in a porcine resource population. Mamm Genome, [Epub ahead of print].

Klatte K, Kirschstein T, Otte D, Pothmann L, Müller L, Tokay T, Kober M, Uebachs M, Zimmer A, Beck H. (2013). Impaired d-serine-mediated cotransmission mediates cognitive dysfunction in epilepsy. J Neurosci, 33(32):13066-80.

Schechter M, Weller A, Pittel Z, Gross M, Zimmer A, Pinhasov A. (2013). Endocannabinoid receptor (CB1R) deficiency affects maternal care and alters the dam's hippocampal oxytocin receptor and BDNF expression. J Neuroendocrinol, doi: 10.1111/jne.12082. [Epub ahead of print].

Schemmer J, Araúzo-Bravo MJ, Haas N, Schäfer S, Weber SN, Becker A, Eckert D, Zimmer A, Nettersheim D, Schorle H. (2013). Transcription Factor TFAP2C Regulates Major Programs Required for Murine Fetal Germ Cell Maintenance and Haploinsufficiency Predisposes to Teratomas in Male Mice. PLoS One, doi: 10.1371/journal.pone.0071113. eCollection 2013.

Borbély E, Hajna Z, Sándor K, Kereskai L, Tóth I, Pintér E, Nagy P, Szolcsányi J, Quinn J, Zimmer A, Stewart J, Paige C, Berger A, Helyes Z. (2013). Role of tachykinin 1 and 4 gene-derived neuropeptides and the neurokinin 1 receptor in adjuvant-induced chronic arthritis of the mouse. PLoS One, doi: 10.1371/journal.pone.0061684. Print 2013.

Siegmund SV, Wojtalla A, Schlosser M, Zimmer A, Singer MV. (2013). Fatty acid amide hydrolase but not monoacyl glycerol lipase controls cell death induced by the endocannabinoid 2-arachidonoyl glycerol in hepatic cell populations. Biochem Biophys Res Commun, 437(1):48-54.

Otte D-M, Barcena de Arellano ML, Bilkei-Gorzo A, Albyram Ö, Imbeault S, Jeung H, Alferink J, Zimmer A. (2013). Effects of Chronic D-Serine Elevation on Animal Models of Depression and Anxiety-Related Behavior. PLoS ONE, 8(6): e67131, doi:10.1371/journal.pone.0067131.

Duerr GD, Heinemann JC, Dunkel S, Zimmer A, Lutz B, Lerner R, Roell W, Mellert F, Probst C, Esmailzadeh B, Welz A, Dewald O. (2013). Myocardial hypertrophy is associated with inflammation and activation of endocannabinoid system in patients with aortic valve stenosis. Life Sci, 92(20-21):976-83.

Botz B, Imreh A, Sándor K, Elekes K, Szolcsányi J, Reglődi D, Quinn JP, Stewart J, Zimmer A, Hashimoto H, Helyes Z. (2013). Role of Pituitary Adenylate-Cyclase Activating Polypeptide and Tac1 gene derived tachykinins in sensory, motor and vascular functions under normal and neuropathic conditions. Peptides, 43:105-12.

Lim S, Becker A, Zimmer A, Lu J, Buettner R, Kirfel J. (2013). SNAI1-Mediated Epithelial-Mesenchymal Transition Confers Chemoresistance and Cellular Plasticity by Regulating Genes Involved in Cell Death and Stem Cell Maintenance. PLoS One, 8(6):e66558. doi: 10.1371/journal.pone.0066558.

Li K, Fichna J, Schicho R, Saur D, Bashashati M, Mackie K, Li Y, Zimmer A, Göke B, Sharkey KA, Storr M. (2013). A role for O-1602 and G protein-coupled receptor GPR55 in the control of colonic motility in mice. Neuropharmacology, 71:255-63.

Kugler JE, Horsch M, Huang D, Furusawa T, Rochman M, Garrett L, Becker L, Bohla A, Hölter SM, Prehn C, Rathkolb B, Racz I, Aguilar-Pimentel JA, Adler T, Adamski J, Beckers J, Busch DH, Eickelberg O, Klopstock T, Ollert M, Stöger T, Wolf E, Wurst W, Yildirim AÖ, Zimmer A, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Garfinkel B, Orly J, Ovcharenko I, Bustin M. (2013). High Mobility Group N Proteins Modulate the Fidelity of the Cellular Transcriptional Profile in a Tissue- and Variant-specific Manner. J Biol Chem, 288(23):16690-703.

Molica F, Burger F, Thomas A, Staub C, Tailleux A, Staels B, Pelli G, Zimmer A, Cravatt B, Matter CM, Pacher P, Steffens S. (2013). Endogenous cannabinoid receptor CB1 activation promotes vascular smooth-muscle cell proliferation and neointima formation. J Lipid Res, 54(5):1360-8.

Becker A, Geisslinger G, Murín R, Grecksch G, Höllt V, Zimmer A, Schröder H. (2013). Cannabinoid-mediated diversity of antinociceptive efficacy of parecoxib in Wistar and Sprague Dawley rats in the chronic constriction injury model of neuropathic pain. Naunyn Schmiedebergs Arch Pharmacol, 386(5):369-82.

Ju L, Wing J, Taylor E, Brandt R, Slijepcevic P, Horsch M, Rathkolb B, Rácz I, Becker L, Hans W, Adler T, Beckers J, Rozman J, Klingenspor M, Wolf E, Zimmer A, Klopstock T, Busch DH, Gailus-Durner V, Fuchs H, Angelis MH, van der Horst G, Lehmann AR. (2013). SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities. DNA Repair, 12:356-366.

Gaffal E, Cron M, Glodde N, Bald T, Kuner R, Zimmer A, Lutz B, Tüting T. (2013). Cannabinoid 1 Receptors in Keratinocytes Modulate Proinflammatory Chemokine Secretion and Attenuate Contact Allergic Inflammation. J Immunol, 190(10):4929-36.

Rácz I, Markert A, Mauer D, Stoffel-Wagner B, Zimmer A. (2013). Long-term ethanol effects on acute stress responses: modulation by dynorphin. Addict Biol, 18(4):678-88.

Drews E, Otte DM, Zimmer A. (2013). Involvement of the primate specific gene G72 in schizophrenia: From genetic studies to pathomechanisms. Neurosci Biobehav Rev, 37:2410-2417.