Publikationen Archiv
Ablation of Hypothalamic Cnr1 Leads to Reduced Meniscal Mineral Volume and Articular Cartilage Damage in Aging Male Mice
Eli Farhat 1 , Michela Palmisano 2 , Miya Marco 1 , Oriya From 1 , Eli Reich 1 , Beat Lutz 3 , Carla F Ramunno 4 , Carmen Ruiz de Almodovar 4 , Andras Bilkei-Gorzo 5 , Mona Dvir-Ginzberg 6
Source: Osteoarthritis Cartilage, PMID: 40865711 DOI: 10.1016/j.joca.2025.08.006
Published: 25 August 2025
Shorter life- and health-span, disturbed insulin-like growth factor signalling in cannabinoid receptor type-1 knockout mice
A Bilkei-Gorzo 1
Source: Experimental Gerontology, PMID: 40553962 DOI: 10.1016/j.exger.2025.112810
Published: September 2025
Fatty-acid amide hydrolase inhibition mitigates Alzheimer's disease progression in mouse models of amyloidosis
Sergio Oddi 1 2 , Lucia Scipioni 2 3 , Antonio Totaro 2 , Giacomo Giacovazzo 1 2 , Francesca Ciaramellano 2 , Daniel Tortolani 2 4 , Alessandro Leuti 2 5 , Rita Businaro 6 , Federica Armeli 6 , Andras Bilkei-Gorzo 7 , Roberto Coccurello 2 8 , Andreas Zimmer 7 , Mauro Maccarrone 2 3
Source: The FEBS Journal, PMID: 39822137 DOI: 10.1111/febs.17403
Published: Januar 2025
Acute high-fat high-sugar diet rapidly increases blood-brain barrier permeability in mice
Leidmaa, E (Leidmaa, Este) [1] , [2] ; Zimmer, A (Zimmer, Andreas) [2] ; Stein, V (Stein, Valentin) [3] ; Gellner, AK (Gellner, Anne-Kathrin) [3] , [4]
Source: ACTA PHYSIOLOGICA
Published SEP 2023
Pharmacological blockade of cannabinoid receptor 2 signaling does not affect LPS/IFN-γ-induced microglial activation (vol 13, 11105, 2023)
Olabiyi, BF (Olabiyi, Bolanle Fatimat) [1] ; Schmoele, AC (Schmoele, Anne-Caroline) [1] ; Beins, EC (Beins, Eva Carolina) [1] , [2] , [3] ; Zimmer, A (Zimmer, Andreas) [1]
Source: SCIENTIFIC REPORT
Published SEP 2023
Possible role of locus coeruleus neuronal loss in age-related memory and attention deficits
Gargano, A (Gargano, Alessandra) [1] ; Olabiyi, BF (Olabiyi, Bolanle Fatimat) [1] ; Palmisano, M (Palmisano, Michela) [1] ; Zimmer, A (Zimmer, Andreas) [1] ; Bilkei-Gorzo, A (Bilkei-Gorzo, Andras)
Source: FRONTIERS IN NEUROSCIENCE
Published AUG 2023
Cannabinoid receptor CB2 antagonist SR144528 blocks LPS/IFN-gamma- induced microglial activation in a CB2 independent manner
Olabiyi, BF (Olabiyi, Bolanle Fatimat) [1] ; Schmöle, AC (Schmoele, Anne-Caroline) [1] ; Beins, E (Beins, Eva) [2] ; Zimmer, A (Zimmer, Andreas) [1]
Source: JOURNAL OF NEUROCHEMISTRY
Published AUG 2023
Impact of AMPA receptors in NG2 glia on signal transmission in the hippocampus and cerebellum
Tascio, D (Tascio, D.) [1] ; Gebril, N (Gebril, N.) [1] ; Seifert, G (Seifert, G.) [1] ; Palmisano, M (Palmisano, M.) ; Kirchhoff, F (Kirchhoff, F.) [2] ; Jabs, R (Jabs, R.) [1] ; Bilkei-Gorzo, A (Bilkei-Gorzo, A.) [3] ; Henneberger, C (Henneberger, C.) [1] , [4] ; Steinhäuser, C (Steinhaeuser, C.) [1]
Source: GLIA
Published JUL 2023
Dysfunction of NG2 glial cells affects neuronal plasticity and behavior
Timmermann, A (Timmermann, Aline) [1] ; Tascio, D (Tascio, Dario) [1] ; Jabs, R (Jabs, Ronald) [1] ; Boehlen, A (Boehlen, Anne) [1] ; Domingos, C (Domingos, Catia) [1] ; Skubal, M (Skubal, Magdalena) [1] ; Huang, WH (Huang, Wenhui) [2] ; Kirchhoff, F (Kirchhoff, Frank) [2] ; Henneberger, C (Henneberger, Christian) [1] , [3] , [4] ; Bilkei-Gorzo, A (Bilkei-Gorzo, Andras) [5] ; Seifert, G (Seifert, Gerald) [1] ; Steinhäuser, C (Steinhaeuser, Christian) [1]
Source GLIA
Published JUN 2023
Chronic low-dose Δ9-tetrahydrocannabinol (THC) treatment stabilizes dendritic spines in 18-month-old mice
Komorowska-Mueller, JA (Komorowska-Mueller, Joanna Agnieszka) [1] ; Gellner, AK (Gellner, Anne-Kathrin) [2] , [3] ; Ravichandran, KA (Ravichandran, Kishore Aravind) [1] , [2] ; Bilkei-Gorzo, A (Bilkei-Gorzo, Andras) [1] ; Zimmer, A (Zimmer, Andreas) [1] ; Stein, V (Stein, Valentin) [2]
Source: SCIENTIFIC REPORTS
Published JAN 2023
Hippocampal Deletion of CB1 Receptor Impairs Social Memory and Leads to Age-Related Changes in the Hippocampus of Adult Mice
Palmisano, M (Palmisano, Michela) [1] ; Gargano, A (Gargano, Alessandra) [1] ; Olabiyi, BF (Olabiyi, Bolanle Fatimat) [1] ; Lutz, B (Lutz, Beat) [2] , [3] ; Bilkei-Gorzo, A (Bilkei-Gorzo, Andras) [1]
Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Published JAN 2023
HU308 Mitigates Osteoarthritis by Stimulating Sox9-Related Networks of Carbohydrate Metabolism
Carmon, I (Carmon, Idan) [1] , [2] ; Zecharyahu, L (Zecharyahu, Lital) [2] ; Elayyan, J (Elayyan, Jinan) [2] ; Meka, SRK (Meka, Sai R. K.) [1] , [2] ; Reich, E (Reich, Eli) [2] ; Kandel, L (Kandel, Leonid) [3] ; Bilkei-Gorzo, A (Bilkei-Gorzo, Andras) [4] ; Zimmer, A (Zimmer, Andreas) [4] ; Mechoulam, R (Mechoulam, Raphael) [1] ; Kravchenko-Balasha, N (Kravchenko-Balasha, Nataly) [2] ; Dvir-Ginzberg, M (Dvir-Ginzberg, Mona) [1] , [2] , [5]
Source: JOURNAL OF BONE AND MINERAL RESEARCH
Published JAN 2023
An astrocytic signaling loop for frequency-dependent control of dendritic integration and spatial learning
Bohmbach, K (Bohmbach, Kirsten) [1] ; Masala, N (Masala, Nicola) [2] ; Schönhense, EM (Schoenhense, Eva M.) [1] ; Hill, K (Hill, Katharina) [1] ; Haubrich, AN (Haubrich, Andre N.) [2] ; Zimmer, A (Zimmer, Andreas) [3] ; Opitz, T (Opitz, Thoralf) [2] ; Beck, H (Beck, Heinz) [2] , [4] ; Henneberger, C (Henneberger, Christian) [1] , [4] , [5
Source: NATURE COMMUNICATIONS (Volume: 13 Issue: 1 DOI: 10.1038/s41467-022-35620-8)
Published DEC 24 2022
Stress vulnerability shapes disruption of motor cortical neuroplasticit
Gellner, AK (Gellner, Anne-Kathrin) [1] ; Sitter, A (Sitter, Aileen) [1] ; Rackiewicz, M (Rackiewicz, Michal) [2] ; Sylvester, M (Sylvester, Marc) [3] ; Philipsen, A (Philipsen, Alexandra) [1] ; Zimmer, A (Zimmer, Andreas) [4] ; Stein, V (Stein, Valentin) [5]
(provided by Clarivate)
TRANSLATIONAL PSYCHIATRY
Volume 12 - Issue 1- Article Number 91 - DOI 10.1038/s41398-022-01855-8-Published MAR 4 2022- Indexed 2022-03-19- Document Type Article
Regulation of adult neurogenesis by the endocannabinoid-producing enzyme diacylglycerol lipase alpha (DAGLa)
Schuele, LL (Schuele, Lena-Louise) [1] ; Schuermann, B (Schuermann, Britta) [1] ; Bilkei-Gorzo, A (Bilkei-Gorzo, Andras) [1] ; Gorgzadeh, S (Gorgzadeh, Sara) [1] ; Zimmer, A (Zimmer, Andreas) [1] ; Leidmaa, E (Leidmaa, Este) [1]
SCIENTIFIC REPORTS
Volume 12 -Issue 1 - Article Number 633 DOI 10.1038/s41598-021-04600-1- Published JAN 12 2022- Indexed 2022-01-26- Document Type Article
Multi-Omics Analysis Reveals Myelin, Presynaptic and Nicotinate Alterations in the Hippocampus of G72/G30 Transgenic Mice
Filiou, MD (Filiou, Michaela D.) [1] , [2] , [3] ; Teplytska, L (Teplytska, Larysa) [1] ; Nussbaumer, M (Nussbaumer, Markus) [2] , [3] ; Otte, DM (Otte, David-M.) [4] , [5] ; Zimmer, A (Zimmer, Andreas) [4] ; Turck, CW (Turck, Christoph W.) [1]
JOURNAL OF PERSONALIZED MEDICINE
Volume12- Issue 2- Article Number 244- DOI 10.3390/jpm12020244 - Published FEB 2022- Indexed 2022-03-27- Document Type Article
Osteogenic growth peptide is a potent anti-inflammatory and bone preserving hormone via cannabinoid receptor type 2
Raphael-Mizrahi, B (Raphael-Mizrahi, Bitya) [1] ; Attar-Namdar, M (Attar-Namdar, Malka) [2] ; Chourasia, M (Chourasia, Mukesh) [3] ; Cascio, MG (Cascio, Maria G.) [4] ; Shurki, A (Shurki, Avital) [3] ; Tam, J (Tam, Joseph) [3] ; Neuman, M (Neuman, Moshe) [2] ; Rimmerman, N (Rimmerman, Neta) [5] ; Vogel, Z (Vogel, Zvi) [5] ; Shteyer, A (Shteyer, Arie) [6] ; Pertwee, RG (Pertwee, Roger G.) [4] ; Zimmer, A (Zimmer, Andreas) [7] ; Kogan, NM (Kogan, Natalya M.) [2] ; Bab, I (Bab, Itai) [2] ; Gabet, Y (Gabet, Yankel) [1] ; Zaidi, M (Zaidi, Mone)
(provided by Clarivate)
ELIFE
Volume 11 - Article Number e65834- DOI 10.7554/eLife.65834- Published MAY 23 2022-Indexed 2022-06-15- Document Type Article
Gargano, A (Gargano, Alessandra)Beins, E (Beins, Eva) Zimmer, A (Zimmer, Andreas) Bilkei-Gorzo, A (Bilkei-Gorzo, Andras. Lack of Cannabinoid Receptor Type-1 Leads to Enhanced Age-Related Neuronal Loss in the Locus Coeruleus . Int. J. Mol. Sci. 2021, 22(1), 5
Beins, EC (Beins, Eva C.) Beiert, T (Beiert, Thomas) Jenniches, I (Jenniches, Imke) Hansen, JN (Hansen, Jan N.) Leidmaa, E (Leidmaa, Este) Schrickel, JW (Schrickel, Jan W.) Zimmer, A (Zimmer, Andreas) Cannabinoid receptor 1 signalling modulates stress susceptibility and microglial responses to chronic social defeat stress Translational Psychiatry volume 11, Article number: 164 (2021)
Schuele LL, Glasmacher S, Gertsch J, Roggan MD, Transfeld JL, Bindila L, Lutz B, Kolbe CC, Bilkei-Gorzo A, Zimmer A, Leidmaa E. (2021). Diacylglycerol lipase alpha in astorcytes is involved in maternal care and affective behaviors. Glia, 69(2):377-391, doi:10.1002/glia.23903.
Ghule A, Rácz I, Bilkei-Gorzo A, Leidmaa E, Sieburg M, Zimmer A. (2020). Modulation of feeding behavior and metabolism by dynorphin. Sci Rep. 10(1):3821. doi: 10.1038/s41598-020-60518-0.
Gaffal E, Kemter AM, Scheu S, Leite Dantas R, Vogt J, Baune B, Tüting T, Zimmer A, Alferink J. (2020). Cannabinoid Receptor 2 Modulates Maturation of Dendritic Cells and Their Capacity to Induce Hapten-Induced Contact Hypersensitivity. Int J Mol Sci., pii: E475. doi: 10.3390/ijms21020475.
Leidmaa E, Gazea M, Patchev AV, Pissioti A, Christian Gassen N, Kimura M, Liposits Z, Kallo I, Almeida OFX. (2020). Blunted leptin sensitivity during hedonic overeating can be reinstated by activating galanin 2 receptors (Gal2R) in the lateral hypothalamus. Acta Physiol (Oxf). 228(2):e13345. doi: 10.1111/apha.13345.
Schürmann B, Bermingham DP, Kopeikina KJ, Myczek K, Yoon S, Horan KE, Kelly CJ, Martin-de-Saavedra MD, Forrest MP, Fawcett-Patel JM, Smith KR, Gao R, Bach A, Burette AC, Rappoport JZ, Weinberg RJ, Martina M, Penzes P. (2020). A novel role for the late-onset Alzheimer's disease (LOAD)-associated protein Bin1 in regulating postsynaptic trafficking and glutamatergic signaling. Mol Psychiatry. doi: 10.1038/s41380-019-0407-3.
Sadahiro M, Demars MP, Burman P, Yevoo P, Zimmer A, Morishita H. (2020). Activation of Somatostatin Interneurons by Nicotinic Modulator Lypd6 Enhances Plasticity and Functional Recovery in the Adult Mouse Visual Cortex. J Neurosci, 40(27):5214-5227, doi:10.1523/JNEUROSCI.1373-19.2020.
Gargano A, Beins E, Zimmer A, Bilkei-Gorzo A. Lack of Cannabinoid Receptor Type-1 Leads to Enhanced Age-Related Neuronal Loss in the Locus Coeruleus. (2020). Int J Mol Sci. 22(1):5. doi: 10.3390/ijms22010005.
Kataoka K, Bilkei-Gorzo A, Nozaki C, Togo A, Nakamura K, Ohta K, Zimmer A, Asahi T. (2020). Age-Dependent Alteration in Mitochondrial Dynamics and Autophagy in Hippocampal Neuron of Cannabinoid CB1 Receptor-deficient Mice. Brain Res Bull, 160:40-49, doi: 10.1016/j.brainresbull.2020.03.014
Zibolka J, Wolf A, Rieger L, Rothgänger C, Jörns A, Lutz B, Zimmer A, Dehghani F, Bazwinsky-Wutschke I. (2020). Influence of Cannabinoid Receptor Deficiency on Parameters Involved in Blood Glucose Regulation in Mice. Int J Mol Sci, doi: 10.3390/ijms21093168.
Cabañero D, Ramírez-López A, Drews E, Schmöle A, Otte DM, Wawrzczak-Bargiela A, Huerga Encabo H, Kummer S, Ferrer-Montiel A, Przewlocki R, Zimmer A, Maldonado R. (2020). Protective role of neuronal and lymphoid cannabinoid CB2 receptors in neuropathic pain. Elife., doi: 10.7554/eLife.55582.
Esteban PF, Garcia-Ovejero D, Paniagua-Torija B, Moreno-Luna R, Arredondo LF, Zimmer A, Arevalo-Martin A, Molina-Holgado E. (2020). Revisiting CB 1 cannabinoid receptor detection and the exploration of its interacting partners. J Neurosci Methods, 1;337:108680. doi: 10.1016/j.jneumeth.2020.108680.
2019
Nent E, Nozaki C, Schmöle AC, Otte D, Zimmer A. (2019). CB2 receptor deletion on myeloid cells enhanced mechanical allodynia in a mouse model of neuropathic pain. Sci Rep, 16;9(1):7468. doi: 10.1038/s41598-019-43858-4.
Yeh YN, Hsin KY, Zimmer A, Lin LY, Hung MS. (2019). A structure-function approach identifies L-PGDS as a mediator responsible for glucocorticoid-induced leptin expression in adipocytes. Biochem Pharmacol 166:203-211. doi: 10.1016/j.bcp.2019.05.022.
Zanos P, Keyworth H, Georgiou P, Hambsch B, Otte DM, Kitchen I, Zimmer A, Bailey A. (2019). Chronic nicotine administration restores brain region specific upregulation of oxytocin receptor binding levels in a G72 mouse model of schizophrenia. Eur J Neurosci., doi: 10.1111/ejn.14155.
Jensen LR, Garrett L, Hölter SM, Rathkolb B, Rácz I, Adler T, Prehn C, Hans W, Rozman J, Becker L, Aguilar-Pimentel JA, Puk O, Moreth K, Dopatka M, Walther DJ, von Bohlen Und Halbach V, Rath M, Delatycki M, Bert B, Fink H, Blümlein K, Ralser M, Van Dijck A, Kooy F, Stark Z, Müller S, Scherthan H, Gecz J, Wurst W, Wolf E, Zimmer A, Klingenspor M, Graw J, Klopstock T, Busch D, Adamski J, Fuchs H, Gailus-Durner V, de Angelis MH, von Bohlen Und Halbach O, Ropers HH, Kuss AW. (2019). A mouse model for intellectual disability caused by mutations in the X-linked 2'‑O‑methyltransferase Ftsj1 gene. Biochim Biophys Acta Mol Basis Dis., pii: S0925-4439(18)30497-6. doi: 10.1016/j.bbadis.2018.12.011.
Duerr GD, Heinemann JC, Kley J, Eichhorn L, Frede S, Weisheit C, Wehner S, Bindila L, Lutz B, Zimmer A, Dewald O. (2019). Myocardial maladaptation to pressure overload in CB2 receptor-deficient mice. J Mol Cell Cardiol, 133:86-98. doi: 10.1016/j.yjmcc.2019.06.003.
Singh K, Jayaram M, Kaare M, Leidmaa E, Jagomäe T, Heinla I, Hickey MA, Kaasik A, Schäfer MK, Innos J, Lilleväli K, Philips MA, Vasar E. (2019). Neural cell adhesion molecule Negr1 deficiency in mouse results in structural brain endophenotypes and behavioral deviations related to psychiatric disorders. Sci Rep., 1;9(1):5457. doi: 10.1038/s41598-019-41991-8.
2018
Schmöle AC, Lundt R, Toporowski G, Hansen JN, Beins E, Halle A, Zimmer A. (2018). Cannabinoid Receptor 2-Deficiency Ameliorates Disease Symptoms in a Mouse Model with Alzheimer's Disease-Like Pathology. J Alzheimers Dis. 64(2):379-392. doi: 10.3233/JAD-180230.
Nozaki C, Nent E, Bilkei-Gorzo A, Zimmer A. (2018). Involvement of leptin signaling in the development of cannabinoid CB2 receptor-dependent mirror image pain. Sci Rep, 8(1):10827. doi: 10.1038/s41598-018-28507-6.
Jehle J, Schöne B, Bagheri S, Avraamidou E, Danisch M, Frank I, Pfeifer P, Bindila L, Lutz B, Lütjohann D, Zimmer A, Nickenig G. (2018). Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE-/- mice. PLoS One 13(5):e0197751. doi: 10.1371/journal.pone.0197751. eCollection 2018.
Bilkei-Gorzo A, Albayram O, Ativie F, Chasan S, Zimmer T, Bach K, Zimmer A. (2018). Cannabinoid 1 receptor signaling on GABAergic neurons influences astrocytes in the ageing brain. PLoS One. 2018 Aug 16;13(8):e0202566. doi: 10.1371/journal.pone.0202566. eCollection 2018.
Ativie F, Komorowska JA, Beins E, Albayram Ö, Zimmer T, Zimmer A, Tejera D, Heneka M, Bilkei-Gorzo A. (2018). Cannabinoid 1 Receptor Signaling on Hippocampal GABAergic Neurons Influences Microglial Activity. Front Mol Neurosci., 11:295. doi: 10.3389/fnmol.2018.00295. eCollection 2018.
Völker LA, Maar BA, Pulido Guevara BA, Bilkei-Gorzo A, Zimmer A, Brönneke H, Dafinger C, Bertsch S, Wagener JR, Schweizer H, Schermer B, Benzing T, Hoehne M. (2018). Neph2/Kirrel3 regulates sensory input, motor coordination, and home-cage activity in rodents. Genes Brain Behav., 17(8):e12516. doi: 10.1111/gbb.12516.
Duerr GD, Feißt A, Halbach K, Verfuerth L, Gestrich C, Wenzel D, Zimmer A, Breuer J, Dewald O. (2018). CB2-deficiency is associated with a stronger hypertrophy and remodeling of the right ventricle in a murine model of left pulmonary artery occlusion. Life Sci., 215:96-105. doi: 10.1016/j.lfs.2018.11.003.
Chen YH, Lee HJ, Lee MT, Wu YT, Lee YH, Hwang LL, Hung MS, Zimmer A, Mackie K, Chiou LC. (2018). Median nerve stimulation induces analgesia via orexin-initiated endocannabinoid disinhibition in the periaqueductal gray. Proc Natl Acad Sci U S A.,115(45):E10720-E10729. doi: 10.1073/pnas.1807991115. Epub 2018 Oct 22.
Fuchs H, Aguilar-Pimentel JA, Amarie OV, Becker L, Calzada-Wack J, Cho YL, Garrett L, Hölter SM, Irmler M, Kistler M, Kraiger M, Mayer-Kuckuk P, Moreth K, Rathkolb B, Rozman J, da Silva Buttkus P, Treise I, Zimprich A, Gampe K, Hutterer C, Stöger C, Leuchtenberger S, Maier H, Miller M, Scheideler A, Wu M, Beckers J, Bekeredjian R, Brielmeier M, Busch DH, Klingenspor M, Klopstock T, Ollert M, Schmidt-Weber C, Stöger T, Wolf E, Wurst W, Yildirim AÖ, Zimmer A, Gailus-Durner V, Hrabě de Angelis M. (2018) Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic. Behav Brain Res 15;352:187-196. doi: 10.1016/j.bbr.2017.09.048.
Garrett L, Becker L, Rozman J, Puk O, Stoeger T, Yildirim AÖ, Bohla A, Eickelberg O, Hans W, Prehn C, Adamski J, Klopstock T, Rácz I, Zimmer A, Klingenspor M, Fuchs H, Gailus-Durner V, Wurst W, Hrabě de Angelis M, Graw J, Hölter SM. (2018). Fgf9 Y162C Mutation Alters Information Processing and Social Memory in Mice. Mol Neurobiol., 55(6):4580-4595. doi: 10.1007/s12035-017-0659-3.
2017
Bilkei-Gorzo A, Albayram O, Draffehn AM, Michel K, Piyanova A, Oppenheimer H, Dvir-Ginzberg M, Rácz I, Ulas T, Imbeault I, Bab I, Schultze JL & Zimmer A. (2017). A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice. Nat Med, doi: nm.4311.
Salminen AV, Garrett L, Schormair B, Rozman J, Giesert F, Niedermeier KM, Becker L, Rathkolb B, Rácz I; German Mouse Clinic Consortium, Klingenspor M, Klopstock T, Wolf E, Zimmer A, Gailus-Durner V, Torres M, Fuchs H, de Angelis MH, Wurst W, Hölter SM, Winkelmann J. (2017). Meis1 effects on motor phenotypes and the sensorimotor system in mice. Dis Model Mech., 10(8):981-991.
Ruland C, Renken H, Kuzmanov I, Fattahi Mehr A, Schwarte K, Cerina M, Herrmann A, Otte DM, Zimmer A, Schwab N, Meuth SG, Arolt V, Klotz L, Förster I, Scheu S, Alferink J. (2017). Chemokine CCL17 is expressed by dendritic cells in the CNS during experimental autoimmune encephalomyelitis and promotes pathogenesis of disease. Brain Behav Immu, 66:382-393.
Xie K, Neff F, Markert A, Rozman J, Aguilar-Pimentel JA, Amarie OV, Becker L, Brommage R, Garrett L, Henzel KS, Hölter SM, Janik D, Lehmann I, Moreth K, Pearson BL, Racz I, Rathkolb B, Ryan DP, Schröder S, Treise I, Bekeredjian R, Busch DH, Graw J, Ehninger G, Klingenspor M, Klopstock T, Ollert M, Sandholzer M, Schmidt-Weber C, Weiergräber M, Wolf E, Wurst W, Zimmer A, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Ehninger D. (2017). Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice. Nat Commun. 24;8(1):155.
Schreiner F, Ackermann M, Michalik M, Hucklenbruch-Rother E, Bilkei-Gorzo A, Racz I, Bindila L, Lutz B, Dötsch J, Zimmer A, Woelfle J. Developmental programming of somatic growth, behavior and endocannabinoid metabolism by variation of early postnatal nutrition in a cross-fostering mouse model. (2017). PLoS One, 12(8):e0182754. doi: 10.1371/journal.pone.0182754. eCollection 2017.
2016
Labuz D, Celik MÖ, Zimmer A, Machelska H. (2016). Distinct roles of exogenous opioid agonists and endogenous opioid peptides in the peripheral control of neuropathy-triggered heat pain. Sci Rep. 6:32799. doi: 10.1038/srep32799.
Fuchs H, Sabrautzki S, Przemeck GK, Leuchtenberger S, Lorenz-Depiereux B, Becker L, Rathkolb B, Horsch M, Garrett L, Östereicher MA, Hans W, Abe K, Sagawa N, Rozman J, Vargas-Panesso IL, Sandholzer M, Lisse TS, Adler T, Aguilar-Pimentel JA, Calzada-Wack J, Ehrhard N, Elvert R, Gau C, Hölter SM, Micklich K, Moreth K, Prehn C, Puk O, Racz I, Stoeger C, Vernaleken A, Michel D, Diener S, Wieland T, Adamski J, Bekeredjian R, Busch DH, Favor J, Graw J, Klingenspor M, Lengger C, Maier H, Neff F, Ollert M, Stoeger T, Yildirim AÖ, Strom TM, Zimmer A, Wolf E, Wurst W, Klopstock T, Beckers J, Gailus-Durner V, Hrabé de Angelis M. (2016). The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations. G3 (Bethesda), 6(12):4035-4046. doi: 10.1534/g3.116.033670.
Kumar S, Rathkolb B, Kemter E, Sabrautzki S, Michel D, Adler T, Becker L, Beckers J, Busch DH, Garrett L, Hans W, Hölter SM, Horsch M, Klingenspor M, Klopstock T, Rácz I, Rozman J, Vargas Panesso IL, Vernaleken A, Zimmer A, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Wolf E, Aigner B. (2016). Generation and Standardized, Systemic Phenotypic Analysis of Pou3f3L423P Mutant Mice. PLoS One. 11(3):e0150472. doi: 10.1371/journal.pone.0150472. eCollection 2016.
Stempel AV, Stumpf A, Zhang HY, Özdoğan T, Pannasch U, Theis AK, Otte DM, Wojtalla A, Rácz I, Ponomarenko A, Xi ZX, Zimmer A, Schmitz D. (2016). Cannabinoid Type 2 Receptors Mediate a Cell Type-Specific Plasticity in the Hippocampus. Neuron, 90(4):795-809.
Pósfai B, Cserép C, Hegedüs P, Szabadits E, Otte DM, Zimmer A, Watanabe M, Freund TF, Nyiri G. (2016). Synaptic and cellular changes induced by the schizophrenia susceptibility gene G72 are rescued by N-acetylcysteine treatment. Transl Psychiatry, 6:e807. doi: 10.1038/tp.2016.74.
Celik MÖ, Labuz D, Henning K, Busch-Dienstfertig M, Gaveriaux-Ruff C, Kieffer BL, Zimmer A, Machelska H. (2016). Leukocyte opioid receptors mediate analgesia via Ca2+-regulated release of opioid peptides. Brain Behav Immun. pii: S0889-1591(16)30109-X. doi: 10.1016/j.bbi.2016.04.018. [Epub ahead of print].
Hou WH, Kuo N, Fang GW, Huang HS, Wu KP, Zimmer A, Cheng JK, Lien CC. (2016). Wiring Specificity and Synaptic Diversity in the Mouse Lateral Central Amygdala. J Neurosci., 36(16):4549-63. doi: 10.1523/JNEUROSCI.3309-15.2016.
Feliszek M, Bindila L, Lutz B, Zimmer A, Bilkei-Gorzo A, Schlicker E. (2016). Lack of hippocampal CB1 receptor desensitization by Δ(9)-tetrahydrocannabinol in aged mice and by low doses of JZL 184. Naunyn Schmiedebergs Arch Pharmacol. 389(6):603-12.
Tung LW, Lu GL, Lee YH, Yu L, Lee HJ, Leishman E, Bradshaw H, Hwang LL, Hung MS, Mackie K, Zimmer A, Chiou LC. (2016). Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons. Nat Commun. 7:12199. doi: 10.1038/ncomms12199.
Alferink J, Specht S, Arends H, Schumak B, Schmidt K, Ruland C, Lundt R, Kemter A, Dlugos A, Kuepper JM, Poppensieker K, Findeiß M, Albayram Ö, Otte DM, Marazzi J, Gertsch J, Förster I, Maier W, Scheu S, Hoerauf A, Zimmer A. (2016). Cannabinoid receptor 2 modulates susceptibility to experimental cerebral malaria through a CCL17-dependent mechanism. J Biol Chem, 2016 Jul 29. pii: jbc.M116.746594. [Epub ahead of print].
Beins E, Ulas T, Ternes S, Neumann H, Schultze JL, Zimmer A. (2016). Characterization of inflammatory markers and transcriptome profiles of differentially activated embryonic stem cell-derived microglia. Glia, 64(6):1007-20.
Beins E, Zimmer A. (2016). Zinc homoeostasis: Basic research indicates therapeutic risks and opportunities. Our Neuropsychopharmacol, 26(6):1083-4.
Zimmer A. (2016). A collaboration investigating endocannabinoid signalling in brain and bone. J Basic Clin Physiol Pharmacy, 27(3):229-35.
Siegmund SV, Wojtalla A, Schlosser M, Schildberg FA, Knolle PA, Nüsing RM, Zimmer A, Strassburg CP, Singer MV. (2016). Cyclooxygenase-2 contributes to the selective induction of cell death by the endocannabinoid 2-arachidonoyl glycerol in hepatic stellate cells. Biochem Biophys Res Commun, 470(3):678-84.
Zimmer A, Otte DM, Bilkei-Gorzo A, Armin SM, Bab I. (2016). Behavioural changes induced by a conditional disruption of bone formation. J Basic Clin Physiol Pharmacy, 27(3):203-7.
Albayram Ö, Passlick S, Bilkei-Gorzo A, Zimmer A, Steinhäuser C. (2016). Physiological impact of CB1 receptor expression by hippocampal GABAergic interneurons. Pflugers Arch, 468(4):727-37.
Jehle J, Hoyer FF, Schöne B, Pfeifer P, Schild K, Jenniches I, Bindila L, Lutz B, Lütjohann D, Zimmer A, Nickenig G. (2016). Myeloid-Specific Deletion of Diacylglycerol Lipase α Inhibits Atherogenesis in ApoE-Deficient Mice. PLoS One, 2016 Jan 5;11(1):e0146267. doi: 10.1371/journal.pone.0146267.
2015
Royeck M, Kelly T, Opitz T, Otte DM, Rennhack A, Woitecki A, Pitsch J, Becker A, Schoch S, Kaupp UB, Yaari Y, Zimmer A, Beck H. (2015). Downregulation of Spermine Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus. J Neurosci. 35(46):15240-53.
Gestrich C, Duerr GD, Heinemann JC, Meertz A, Probst C, Roell W, Schiller W, Zimmer A, Bindila L, Lutz B, Welz A, Dewald O. (2015). Activation of Endocannabinoid System Is Associated with Persistent Inflammation in Human Aortic Aneurysm. Biomed Res Int, 2015:456582. doi: 10.1155/2015/456582. Epub 2015 Oct 11.
Ruhl T, Jonas A, Seidel NI, Prinz N, Albayram O, Bilkei-Gorzo A, von der Emde G. (2015). Oxidation and Cognitive Impairment in the Aging Zebrafish. Gerontology, 62(1):47-57.
Zimmer A. (2015). Genetic Manipulation of the Endocannabinoid System. Handb Exp Pharmacol, 231:129-83.
de Angelis MH, Nicholson G, Selloum M, White JK, Morgan H, Ramirez-Solis R, Sorg T, Wells S, Fuchs H, Fray M, Adams DJ, Adams NC, Adler T, Aguilar-Pimentel A, Ali-Hadji D, Amann G, André P, Atkins S, Auburtin A, Ayadi A, Becker J, Becker L, Bedu E, Bekeredjian R, Birling MC, Blake A, Bottomley J, Bowl MR, Brault V, Busch DH, Bussell JN, Calzada-Wack J, Cater H, Champy MF, Charles P, Chevalier C, Chiani F, Codner GF, Combe R, Cox R, Dalloneau E, Dierich A, Di Fenza A, Doe B, Duchon A, Eickelberg O, Esapa CT, Fertak LE, Feigel T, Emelyanova I, Estabel J, Favor J, Flenniken A, Gambadoro A, Garrett L, Gates H, Gerdin AK, Gkoutos G, Greenaway S, Glasl L, Goetz P, Da Cruz IG, Götz A, Graw J, Guimond A, Hans W, Hicks G, Hölter SM, Höfler H, Hancock JM, Hoehndorf R, Hough T, Houghton R, Hurt A, Ivandic B, Jacobs H, Jacquot S, Jones N, Karp NA, Katus HA, Kitchen S, Klein-Rodewald T, Klingenspor M, Klopstock T, Lalanne V, Leblanc S, Lengger C, le Marchand E, Ludwig T, Lux A, McKerlie C, Maier H, Mandel JL, Marschall S, Mark M, Melvin DG, Meziane H, Micklich K, Mittelhauser C, Monassier L, Moulaert D, Muller S, Naton B, Neff F, Nolan PM, Nutter LM, Ollert M, Pavlovic G, Pellegata NS, Peter E, Petit-Demoulière B, Pickard A, Podrini C, Potter P, Pouilly L, Puk O, Richardson D, Rousseau S, Quintanilla-Fend L, Quwailid MM, Racz I, Rathkolb B, Riet F, Rossant J, Roux M, Rozman J, Ryder E, Salisbury J, Santos L, Schäble KH, Schiller E, Schrewe A, Schulz H, Steinkamp R, Simon M, Stewart M, Stöger C, Stöger T, Sun M, Sunter D, Teboul L, Tilly I, Tocchini-Valentini GP, Tost M, Treise I, Vasseur L, Velot E, Vogt-Weisenhorn D, Wagner C, Walling A, Wattenhofer-Donze M, Weber B, Wendling O, Westerberg H, Willershäuser M, Wolf E, Wolter A, Wood J, Wurst W, Yildirim AÖ, Zeh R, Zimmer A, Zimprich A; EUMODIC Consortium, Holmes C, Steel KP, Herault Y, Gailus-Durner V, Mallon AM, Brown SD. (2015). Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics. Nat Genet, 47(9):969-78.
Jenniches I, Zimmer A. (2015). Reply To: The Anxiolytic Actions of 2-Arachidonoylglycerol: Converging Evidence from Two Recent Genetic Endocannabinoid Deficiency Models. Boil Psychiatry, 79(10):e80-1.
Schmöle AC, Lundt R, Gennequin B, Schrage H, Beins E, Krämer A, Zimmer T, Limmer A, Zimmer A, Otte DM. (2015). Expression Analysis of CB2-GFP BAC Transgenic Mice. PLoS One. 2015 Sep 25;10(9):e0138986. doi: 10.1371/journal.pone.0138986. eCollection 2015.
Piyanova A, Lomazzo E, Bindila L, Lerner R, Albayram O, Ruhl T, Lutz B, Zimmer A, Bilkei-Gorzo A. (2015). Age-related changes in the endocannabinoid system in the mouse hippocampus. Mech Ageing Dev, 150:55-64.
Kemter AM, Scheu S, Hüser N, Ruland C, Schumak B, Findeiß M, Cheng Z, Assfalg V, Arolt V, Zimmer A, Alferink J. (2015). The cannabinoid receptor 2 is involved in acute rejection of cardiac allografts. Life Sci, 138:29-34.
Nozaki C, Markert A, Zimmer A. (2015). Inhibition of FAAH reduces nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity in mice. Eur Neuropsychopharmacol, 25(8):1388-96.
Saarikangas J, Kourdougli N, Senju Y, Chazal G, Segerstråle M, Minkeviciene R, Kuurne J, Mattila PK, Garrett L, Hölter SM, Becker L, Racz I, Hans W, Klopstock T, Wurst W, Zimmer A, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, von Ossowski L, Taira T, Lappalainen P, Rivera C, Hotulainen P. (2015). MIM-Induced Membrane Bending Promotes Dendritic Spine Initiation. Dev Cell, 33(6):644-59.
Dewald O, Zimmer A. (2015). Endocannabinoids in adaptation to injury: Ready to move from bench to bedside? Life Sci. 2015 Jun 17. pii: S0024-3205(15)00308-2. doi: 10.1016/j.lfs.2015.06.003. [Epub ahead of print].
Jenniches I, Ternes S, Albayram O, Otte DM, Bach K, Bindila L, Michel K, Lutz B, Bilkei-Gorzo A, Zimmer A. (2015). Anxiety, Stress, and Fear Response in Mice with Reduced Endocannabinoid Levels. Biol Psychiatry, 2015 Apr 14. pii: S0006-3223(15)00314-5. doi: 10.1016/j.biopsych.2015.03.033. [Epub ahead of print].
Pradier B, Erxlebe E, Markert A, Rácz I. (2015). Interaction of cannabinoid receptor 2 and social environment modulates chronic alcohol consumption. Behav Brain Res. 2015 Mar 28;287:163-171. doi: 10.1016/j.bbr.2015.03.051. [Epub ahead of print].
Maccarrone M, Bab I, Bíró T, Cabral GA, Dey SK, Di Marzo V, Konje JC, Kunos G, Mechoulam R, Pacher P, Sharkey KA, Zimmer A. (2015). Endocannabinoid signaling at the periphery: 50 years after THC. Trends Pharmacol Sci. 2015 Mar 18. pii: S0165-6147(15)00034-6. doi: 10.1016/j.tips.2015.02.008. [Epub ahead of print].
Rácz I, Nent E, Erxlebe E, Zimmer A. (2015). CB1 receptors modulate affective behaviour induced by neuropathic pain. Brain Res Bull, 2015 Apr 8. pii: S0361-9230(15)00059-3. doi: 10.1016/j.brainresbull.2015.03.005. [Epub ahead of print].
Sturm M, Becker A, Schroeder A, Bilkei-Gorzo A, Zimmer A. (2015). Effect of chronic corticosterone application on depression-like behavior in C57BL/6N and C57BL/6J mice. Genes Brain Behav, 14(3):292-300.
Schmöle AC, Lundt R, Ternes S, Albayram O, Ulas T, Schultze JL, Bano D, Nicotera P, Alferink J, Zimmer A. (2015). Cannabinoid receptor 2 deficiency results in reduced neuroinflammation in an Alzheimer's disease mouse model. Neurobiol Aging, 36:710-719.
Di Marzo V, Stella A, Zimmer A. (2015). Endocannabinoid signaling and the deteriorating brain. Nature Rev. Neurosci., 16(1):30-42.
Wasserman E, Tam J, Mechoulam R, Zimmer A, Maor G, Bab I. (2015). CB1 cannabinoid receptors mediate endochondral skeletal growth attenuation by Δ9-tetrahydrocannabinol. In "MARROW", ed. by M. Zaidi. Ann N Y Acad Sci, 1335(1):110-119.
Ativie F, Albayram O, Bach K, Pradier B, Zimmer A, Bilkei-Gorzo A. (2015). Enhanced microglial activity in FAAH-/- animals. Life Sci, 138:52-56.
2014
Niedermair T, Kuhn V, Doranehgard F, Stange R, Wieskötter B, Beckmann J, Salem P, Springorum HR, Straub RH, Zimmer A, Grifka J, Grässel S. (2014). Absence of substance P and the sympathetic nervous system impact on bone structure and chondrocyte differentiation in an adult model of endochondral ossification. Matrix Biol. 38: 22–35.
Heinemann JC, Duerr GD, Keppel K, Breitbach M, Fleischmann BK, Zimmer A, Wehner S, Welz A, Dewald O. (2014). CB2 receptor-mediated effects of pro-inflammatory macrophages influence survival of cardiomyocytes. Life Sci, pii: S0024-3205(14)00948-5. doi: 10.1016/j.lfs.2014.11.027. [Epub ahead of print].
Duerr GD, Heinemann JC, Gestrich C, Heuft T, Klaas T, Keppel K, Roell W, Klein A, Zimmer A, Velten M, Kilic A, Bindila L, Lutz B, Dewald O. (2014). Impaired border zone formation and adverse remodeling after reperfused myocardial infarction in cannabinoid CB2 receptor deficient mice. Life Sci, 2014 Nov 14. pii: S0024-3205(14)00915-1. doi: 10.1016/j.lfs.2014.11.005. [Epub ahead of print].
Mongi-Bragato B, Zamponi E, García-Keller C, Assis MA, Virgolini MB, Mascó DH, Zimmer A, Cancela LM. (2014). Enkephalin is essential for the molecular and behavioral expression of cocaine sensitization. Addict Biol, 2014 Nov 27. doi: 10.1111/adb.12200. [Epub ahead of print].
Thor T, Künkele A, Pajtler KW, Wefers AK, Stephan H, Mestdagh P, Heukamp L, Hartmann W, Vandesompele J, Sadowski N, Becker L, Garrett L, Hölter SM, Horsch M, Calzada-Wack J, Klein-Rodewald T, Racz I, Zimmer A, Beckers J, Neff F, Klopstock T, De Antonellis P, Zollo M, Wurst W, Fuchs H, Gailus-Durner V, Schüller U, Hraběde Angelis M, Eggert A, Schramm A, Schulte JH. (2014). MiR-34a deficiency accelerates medulloblastoma formation in vivo. Int J Cancer, 2014 Oct 27. doi: 10.1002/ijc.29294. [Epub ahead of print].
Wood PL, Filiou MD, Otte DM, Zimmer A, Turck CW. (2014). Lipidomics reveals dysfunctional glycosynapses in schizophrenia and the G72/G30 transgenic mouse. Schizophr Res, 159(2-3):365-9.
Forstner AJ, Basmanav FB, Mattheisen M, Böhmer AC, Hollegaard MV, Janson E, Strengman E, Priebe L, Degenhardt F, Hoffmann P, Herms S, Maier W, Mössner R, Rujescu D, Ophoff RA, Moebus S, Mortensen PB, Børglum AD, Hougaard DM, Frank J, Witt SH, Rietschel M, Zimmer A, Nöthen MM, Miró X, Cichon S; GROUP Investigators. (2014). Investigation of the involvement of MIR185 and its target genes in the development of schizophrenia. Psychiatry Neurosci, 39(6):386-96.
Otte DM, Raskó T, Wang M, Dreiseidler M, Drews E, Schrage H, Wojtalla A, Höhfeld J, Wanker E, Zimmer A. (2014). Identification of the Mitochondrial MSRB2 as a Binding Partner of LG72. Cell Mol Neurobiol, 34(8):1123-30.
Kemter E, Rathkolb B, Becker L, Bolle I, Busch DH, Dalke C, Elvert R, Favor J, Graw J, Hans W, Ivandic B, Kalaydjiev S, Klopstock T, Rácz I, Rozman J, Schrewe A, Schulz H, Zimmer A, Fuchs H, Gailus-Durner V, de Angelis M, Wolf E, Aigner B. (2014). Standardized, systemic phenotypic analysis of Slc12a1I299F mutant mice. J Biomed Sci, 2014 Aug 2;21(1):68. [Epub ahead of print].
Duerr GD, Heinemann JC, Suchan G, Kolobara E, Wenzel D, Geisen C, Matthey M, Passe-Tietjen K, Mahmud W, Ghanem A, Tiemann K, Alferink J, Burgdorf S, Buchalla R, Zimmer A, Lutz B, Welz A, Fleischmann BK, Dewald O. (2014). The endocannabinoid-CB2 receptor axis protects the ischemic heart at the early stage of cardiomyopathy. Basic Res Cardiol, 109(4):425.
Melo I, Drews E, Zimmer A, Bilkei-Gorzo A. (2014). Enkephalin knockout male mice are resistant to chronic mild stress. Genes Brain Behav. 13(6):550-8.
Zumbrennen-Bullough KB, Becker L, Garrett L, Hölter SM, Calzada-Wack J, Mossbrugger I, Quintanilla-Fend L, Racz I, Rathkolb B, Klopstock T, Wurst W, Zimmer A, Wolf E, Fuchs H, Gailus-Durner V, de Angelis MH, Romney SJ, Leibold EA. (2014). Abnormal Brain Iron Metabolism in Irp2 Deficient Mice Is Associated with Mild Neurological and Behavioral Impairments. PLoS One, 2014 Jun 4;9(6):e98072. doi: 10.1371/journal.pone.0098072. eCollection 2014.
Friemel CM, Zimmer A, Schneider M. (2014). The CB1 Receptor as an Important Mediator of Hedonic Reward Processing. Neuropsychopharmacology, 39(10):2387-96.
Bilkei-Gorzo A, Mauer D, Michel K, Zimmer A. (2014). Dynorphins regulate the strength of social memory. Neuropharmacology. 77:406-413.
Pradier B, Jeub M, Markert A, Mauer D, Tolksdorf K, Van de Putte T, Seuntjens E, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Huylebroeck D, Beck H, Zimmer A, Rácz I. (2014). Smad-interacting protein 1 affects acute and tonic, but not chronic pain. Eur J Pain, 18(2):249-57.
Hambsch B, Keyworth H, Lind J, Otte DM, Racz I, Kitchen I, Bailey A, Zimmer A. (2014). Chronic nicotine improves short-term memory selectively in a G72 mouse model of schizophrenia. Br J Pharmacol, doi: 10.1111/bph.12578. [Epub ahead of print].
Kubaczka C, Senner C, Araúzo-Bravo MJ, Sharma N, Kuckenberg P, Becker A, Zimmer A, Brüstle O, Peitz M, Hemberger M, Schorle H. (2014). Derivation and Maintenance of Murine Trophoblast Stem Cells under Defined Conditions. Stem Cell Reports, 30;2(2):232-42.
Szitter I, Pintér E, Perkecz A, Kemény A, Kun J, Kereskai L, Pietra C, Quinn JP, Zimmer A, Berger A, Paige CJ, Helyes Z. (2014). Role of neurokinin 1 receptors in dextran sulfate-induced colitis: studies with gene-deleted mice and the selective receptor antagonist netupitant. Inflamm Res, 63:399-409.
Barth A, Bilkei-Gorzo A, Drews E, Otte DM, Diaz-Lacava A, Varadarajulu J, Turck CW, Wienker TF, Zimmer A. (2014). Analysis of quantitative trait loci in mice suggests a role of Enoph1 in stress reactivity. J Neurochem, 128(6):807-17.
2013
Hoyer FF, Khoury M, Slomka H, Kebschull M, Lerner R, Lutz B, Schott H, Lütjohann D, Wojtalla A, Becker A, Zimmer A, Nickenig G. (2013). Inhibition of endocannabinoid-degrading enzyme fatty acid amide hydrolase increases atherosclerotic plaque vulnerability in mice. J Mol Cell Cardiol, 66C:126-132.
Gennequin B, Otte DM, Zimmer A. (2013). CRISPR/Cas-induced double-strand breaks boost the frequency of gene replacements for humanizing the mouse Cnr2 gene. Biochem Biophys Res Commun., 441:815-819.
Neff F, Flores-Dominguez D, Ryan DP, Horsch M, Schröder S, Adler T, Afonso LC, Aguilar-Pimentel JA, Becker L, Garrett L, Hans W, Hettich MM, Holtmeier R, Hölter SM, Moreth K, Prehn C, Puk O, Rácz I, Rathkolb B, Rozman J, Naton B, Ordemann R, Adamski J, Beckers J, Bekeredjian R, Busch DH, Ehninger G, Graw J, Höfler H, Klingenspor M, Klopstock T, Ollert M, Stypmann J, Wolf E, Wurst W, Zimmer A, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Ehninger D. (2013). Rapamycin extends murine lifespan but has limited effects on aging. J. Clin. Invest., 123(8):3272-91.
Klauke AL, Racz I, Pradier B, Markert A, Zimmer AM, Gertsch J, Zimmer A. (2013). The cannabinoid CB2 receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic pain. Eur Neuropsychopharmacol, 24(4):608-20.
Wenzel D, Matthey M, Bindila L, Lerner R, Lutz B, Zimmer A, Fleischmann BK. (2013). Endocannabinoid anandamide mediates hypoxic pulmonary vasoconstriction. Proc Natl Acad Sci U S A. 110(46):18710-5.
Montani G, Tonelli S, Sanghez V, Ferrari PF, Palanza P, Zimmer A, Tirindelli R. (2013). Aggressive behaviour and physiological responses to pheromones are strongly impaired in mice deficient for the olfactory G-protein -subunit G8. J Physiol., 591:3949-62.
Heidt H, Cinar MU, Uddin MJ, Looft C, Jüngst H, Tesfaye D, Becker A, Zimmer A, Ponsuksili S, Wimmers K, Tholen E, Schellander K, Große-Brinkhaus C. (2013). A genetical genomics approach reveals new candidates and confirms known candidate genes for drip loss in a porcine resource population. Mamm Genome, [Epub ahead of print].
Klatte K, Kirschstein T, Otte D, Pothmann L, Müller L, Tokay T, Kober M, Uebachs M, Zimmer A, Beck H. (2013). Impaired d-serine-mediated cotransmission mediates cognitive dysfunction in epilepsy. J Neurosci, 33(32):13066-80.
Schechter M, Weller A, Pittel Z, Gross M, Zimmer A, Pinhasov A. (2013). Endocannabinoid receptor (CB1R) deficiency affects maternal care and alters the dam's hippocampal oxytocin receptor and BDNF expression. J Neuroendocrinol, doi: 10.1111/jne.12082. [Epub ahead of print].
Schemmer J, Araúzo-Bravo MJ, Haas N, Schäfer S, Weber SN, Becker A, Eckert D, Zimmer A, Nettersheim D, Schorle H. (2013). Transcription Factor TFAP2C Regulates Major Programs Required for Murine Fetal Germ Cell Maintenance and Haploinsufficiency Predisposes to Teratomas in Male Mice. PLoS One, doi: 10.1371/journal.pone.0071113. eCollection 2013.
Borbély E, Hajna Z, Sándor K, Kereskai L, Tóth I, Pintér E, Nagy P, Szolcsányi J, Quinn J, Zimmer A, Stewart J, Paige C, Berger A, Helyes Z. (2013). Role of tachykinin 1 and 4 gene-derived neuropeptides and the neurokinin 1 receptor in adjuvant-induced chronic arthritis of the mouse. PLoS One, doi: 10.1371/journal.pone.0061684. Print 2013.
Siegmund SV, Wojtalla A, Schlosser M, Zimmer A, Singer MV. (2013). Fatty acid amide hydrolase but not monoacyl glycerol lipase controls cell death induced by the endocannabinoid 2-arachidonoyl glycerol in hepatic cell populations. Biochem Biophys Res Commun, 437(1):48-54.
Otte D-M, Barcena de Arellano ML, Bilkei-Gorzo A, Albyram Ö, Imbeault S, Jeung H, Alferink J, Zimmer A. (2013). Effects of Chronic D-Serine Elevation on Animal Models of Depression and Anxiety-Related Behavior. PLoS ONE, 8(6): e67131, doi:10.1371/journal.pone.0067131.
Duerr GD, Heinemann JC, Dunkel S, Zimmer A, Lutz B, Lerner R, Roell W, Mellert F, Probst C, Esmailzadeh B, Welz A, Dewald O. (2013). Myocardial hypertrophy is associated with inflammation and activation of endocannabinoid system in patients with aortic valve stenosis. Life Sci, 92(20-21):976-83.
Botz B, Imreh A, Sándor K, Elekes K, Szolcsányi J, Reglődi D, Quinn JP, Stewart J, Zimmer A, Hashimoto H, Helyes Z. (2013). Role of Pituitary Adenylate-Cyclase Activating Polypeptide and Tac1 gene derived tachykinins in sensory, motor and vascular functions under normal and neuropathic conditions. Peptides, 43:105-12.
Lim S, Becker A, Zimmer A, Lu J, Buettner R, Kirfel J. (2013). SNAI1-Mediated Epithelial-Mesenchymal Transition Confers Chemoresistance and Cellular Plasticity by Regulating Genes Involved in Cell Death and Stem Cell Maintenance. PLoS One, 8(6):e66558. doi: 10.1371/journal.pone.0066558.
Li K, Fichna J, Schicho R, Saur D, Bashashati M, Mackie K, Li Y, Zimmer A, Göke B, Sharkey KA, Storr M. (2013). A role for O-1602 and G protein-coupled receptor GPR55 in the control of colonic motility in mice. Neuropharmacology, 71:255-63.
Kugler JE, Horsch M, Huang D, Furusawa T, Rochman M, Garrett L, Becker L, Bohla A, Hölter SM, Prehn C, Rathkolb B, Racz I, Aguilar-Pimentel JA, Adler T, Adamski J, Beckers J, Busch DH, Eickelberg O, Klopstock T, Ollert M, Stöger T, Wolf E, Wurst W, Yildirim AÖ, Zimmer A, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Garfinkel B, Orly J, Ovcharenko I, Bustin M. (2013). High Mobility Group N Proteins Modulate the Fidelity of the Cellular Transcriptional Profile in a Tissue- and Variant-specific Manner. J Biol Chem, 288(23):16690-703.
Molica F, Burger F, Thomas A, Staub C, Tailleux A, Staels B, Pelli G, Zimmer A, Cravatt B, Matter CM, Pacher P, Steffens S. (2013). Endogenous cannabinoid receptor CB1 activation promotes vascular smooth-muscle cell proliferation and neointima formation. J Lipid Res, 54(5):1360-8.
Becker A, Geisslinger G, Murín R, Grecksch G, Höllt V, Zimmer A, Schröder H. (2013). Cannabinoid-mediated diversity of antinociceptive efficacy of parecoxib in Wistar and Sprague Dawley rats in the chronic constriction injury model of neuropathic pain. Naunyn Schmiedebergs Arch Pharmacol, 386(5):369-82.
Ju L, Wing J, Taylor E, Brandt R, Slijepcevic P, Horsch M, Rathkolb B, Rácz I, Becker L, Hans W, Adler T, Beckers J, Rozman J, Klingenspor M, Wolf E, Zimmer A, Klopstock T, Busch DH, Gailus-Durner V, Fuchs H, Angelis MH, van der Horst G, Lehmann AR. (2013). SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities. DNA Repair, 12:356-366.
Gaffal E, Cron M, Glodde N, Bald T, Kuner R, Zimmer A, Lutz B, Tüting T. (2013). Cannabinoid 1 Receptors in Keratinocytes Modulate Proinflammatory Chemokine Secretion and Attenuate Contact Allergic Inflammation. J Immunol, 190(10):4929-36.
Rácz I, Markert A, Mauer D, Stoffel-Wagner B, Zimmer A. (2013). Long-term ethanol effects on acute stress responses: modulation by dynorphin. Addict Biol, 18(4):678-88.
Drews E, Otte DM, Zimmer A. (2013). Involvement of the primate specific gene G72 in schizophrenia: From genetic studies to pathomechanisms. Neurosci Biobehav Rev, 37:2410-2417.
2012
Neely GG, Rao S, Costigan M, Mair N, Racz I, Milinkeviciute G, Meixner A, Nayanala S, Griffin RS, Belfer I, Dai F, Smith S, Diatchenko L, Marengo S, Haubner BJ, Novatchkova M, Gibson D, Maixner W, Pospisilik JA, Hirsch E, Whishaw IQ, Zimmer A, Gupta V, Sasaki J, Kanaho Y, Sasaki T, Kress M, Woolf CJ, Penninger JM. (2012). Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. PLoS Genet, doi: 10.1371/ journal.pgen.1003071.
Albayram O, Bilkei-Gorzo A, Zimmer A. (2012). Loss of CB1 receptors leads to differential age-related changes in reward-driven learning and memory. Front Aging Neurosci, 4:34. doi: 10.3389/fnagi.2012.00034.
Berner J, Shvarev Y, Zimmer A, Wickström R. (2012). Hypoxic ventilatory response in Tac1 -/- neonatal mice following exposure to opioids. J Appl Physiol, 14(1):11-22.
Fuchs H, Gailus-Durner V, Neschen S, Adler T, Afonso LC, Aguilar-Pimentel JA, Becker L, Bohla A, Calzada-Wack J, Cohrs C, Dewert A, Fridrich B, Garrett L, Glasl L, Götz A, Hans W, Hölter SM, Horsch M, Hurt A, Janas E, Janik D, Kahle M, Kistler M, Klein-Rodewald T, Lengger C, Ludwig T, Maier H, Marschall S, Micklich K, Möller G, Naton B, Prehn C, Puk O, Rácz I, Räß M, Rathkolb B, Rozman J, Scheerer M, Schiller E, Schrewe A, Steinkamp R, Stöger C, Sun M, Szymczak W, Treise I, Vargas Panesso IL, Vernaleken AM, Willershäuser M, Wolff-Muscate A, Zeh R, Adamski J, Beckers J, Bekeredjian R, Busch DH, Eickelberg O, Favor J, Graw J, Höfler H, Höschen C, Katus H, Klingenspor M, Klopstock T, Neff F, Ollert M, Schulz H, Stöger T, Wolf E, Wurst W, Yildirim AO, Zimmer A, Hrabě de Angelis M. (2012). Innovations in phenotyping of mouse models in the German Mouse Clinic. Mamm Genome, 23(9-10):611-22.
Miró X, Meier S, Dreisow ML, Frank J, Strohmaier J, Breuer R, Schmäl C, Albayram O, Pardo-Olmedilla MT, Mühleisen TW, Degenhardt FA, Mattheisen M, Reinhard I, Bilkei-Gorzo A, Cichon S, Seidenbecher C, Rietschel M, Nöthen MM, Zimmer A. (2012). Studies in humans and mice implicate neurocan in the etiology of mania. Am J Psychiatry,169(9):982-90.
Scheef L, Jankowski J, Daamen M, Weyer G, Klingenberg M, Renner J, Mueckter S, Schürmann B, Musshoff F, Wagner M, Schild HH, Zimmer A, Boecker H. (2012). An fMRI study on the acute effects of exercise on pain processing in trained athletes. Pain, 153(8):1702-14.
Gregg LC, Jung KM, Spradley JM, Nyilas R, Suplita RL 2nd, Zimmer A, Watanabe M, Mackie K, Katona I, Piomelli D, Hohmann AG. (2012). Activation of Type 5 Metabotropic Glutamate Receptors and Diacylglycerol Lipase-α Initiates 2-Arachidonoylglycerol Formation and Endocannabinoid-Mediated Analgesia. J Neurosci, 32(28):9457-9468.
Janzer A, Stamm K, Becker A, Zimmer A, Buettner R, Kirfel J. (2012). The H3K4me3 histone demethylase Fbxl10 is a regulator of chemokine expression, cellular morphology and the metabolome of fibroblasts. J Biol Chem, 287:30984-30992.
Filiou MD, Teplytska L, Otte DM, Zimmer A, Turck CW. (2012). Myelination and oxidative stress alterations in the cerebellum of the G72/G30 transgenic schizophrenia mouse model. J Psychiatr Res, 46(10):1359-65.
Bilkei-Gorzo A, Erk S, Schürmann B, Mauer D, Michel K, Boecker H, Scheef L, Walter H, Zimmer A. (2012). Dynorphins regulate fear memory: from mice to men. J Neurosci, 32(27):9335-43.
Sugawara K, Bíró T, Tsuruta D, Tóth BI, Kromminga A, Zákány N, Zimmer A, Funk W, Gibbs BF, Zimmer A, Paus R. (2012). Endocannabinoids limit excessive mast cell maturation and activation in human skin. J Allergy Clin Immunol, 129(3):726-738.e8.
Staropoli JF, Haliw L, Biswas S, Garrett L, Hölter SM, Becker L, Skosyrski S, Da Silva-Buttkus P, Calzada-Wack J, Neff F, Rathkolb B, Rozman J, Schrewe A, Adler T, Puk O, Sun M, Favor J, Racz I, Bekeredjian R, Busch DH, Graw J, Klingenspor M, Klopstock T, Wolf E, Wurst W, Zimmer A, Lopez E, Harati H, Hill E, Krause DS, Guide J, Dragileva E, Gale E, Wheeler VC, Boustany RM; Brown DE, Breton S, Ruether K, Gailus-Durner V, Fuchs H, Hrabé de Angelis M, Cotman SL. (2012). Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system. PLoS ONE 7 (6), e38310.
John Lin CC, Chen WN, Chen CJ, Lin YW, Zimmer A, Chen CC. (2012). An antinociceptive role for substance P in acid-induced chronic muscle pain. Proc Natl Acad Sci U S A, 109(2):E76-83.
Schulte K, Steingrüber N, Jergas B, Redmer A, Kurz CM, Buchalla R, Lutz B, Zimmer A, Schlicker E. (2012). Cannabinoid CB(1) receptor activation, pharmacological blockade, or genetic ablation affects the function of the muscarinic auto- and heteroreceptor. Naunyn Schmiedebergs Arch Pharmacol, 385(4):385-96.
Wojtalla A, Herweck F, Granzow M, Klein S, Trebicka J, Huss S, Lerner R, Lutz B, Schildberg FA, Knolle PA, Sauerbruch T, Singer MV, Zimmer A, Siegmund SV. (2012). The endocannabinoid N-arachidonoyl dopamine (NADA) selectively induces oxidative stress-mediated cell death in hepatic stellate cells, but not in hepatocytes. Am J Physiol Gastrointest Liver Physiol, 302: G873–G887.
Poppensieker K, Otte DM, Schürmann B, Limmer A, Dresing P, Drews E, Schumak B, Klotz L, Raasch J, Mildner A, Waisman A, Scheu S, Knolle P, Förster I, Prinz M, Maier W, Zimmer A, Alferink J. (2012). CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells. Proc Natl Acad Sci U S A, 109(10): 3897-3902.
Molica F, Matter CM, Burger F, Pelli G, Lenglet S, Zimmer A, Pacher P, Steffens S. (2012). The cannabinoid receptor CB2 protects against balloon-induced neointima formation. Am J Physiol Heart Circ Physiol, 302:H1064-H1074.
Zádor F, Otvös F, Benyhe S, Zimmer A, Páldy E. (2012). Inhibition of forebrain μ-opioid receptor signaling by low concentrations of rimonabant does not require cannabinoid receptors and directly involves μ-opioid receptors. Neurochem Int. [Epub ahead of print].
Helmut Fuchs, Susanne Neschen, Jan Rozman, Birgit Rathkolb, Sibylle Wagner, Thure Adler, Luciana Afonso, Juan Antonio Aguilar-Pimentel, Lore Becker, Alexander Bohla, Julia Calzada-Wack, Christian Cohrs, András Frankó, Lillian Garrett, Lisa Glasl, Alexander Götz, Michael Hagn, Wolfgang Hans, Sabine M. Hölter, Marion Horsch, Melanie Kahle, Martin Kistler, Tanja Klein-Rodewald, Christoph Lengger, Tonia Ludwig, Holger Maier, Susan Marschall, Kateryna Micklich, Gabriele Möller, Beatrix Naton, Frauke Neff, Cornelia Prehn, Oliver Puk, Ildikó Rácz, Michael Räß, Markus Scheerer, Evelyn Schiller, Felix Schöfer, Anja Schrewe, Ralph Steinkamp, Claudia Stöger, Irina Treise, Monja Willershäuser, Annemarie Wolff-Muscate, Ramona Zeh, Jerzy Adamski, Johannes Beckers, Raffi Bekeredjian, Dirk H. Busch, Jack Favor, Jochen Graw, Hugo Katus, Thomas Klopstock, Markus Ollert, Holger Schulz, Tobias Stöger, Wolfgang Wurst, Ali Önder Yildirim, Andreas Zimmer, Eckhard Wolf, Martin Klingenspor, Valérie Gailus-Durner, and Martin Hrabě de Angelis. (2012). Chapter 7: Mouse Genetics and Metabolic Mouse Phenotyping. In: K. Suhre (ed.), Genetics Meets Metabolomics: from Experiment to Systems Biology, 85, DOI 10.1007/978-1-4614-1689-0_7, © Springer Science+Business Media, LLC 2012
2011
Louvet A, Teixeira-Clerc F, Chobert MN, Deveaux V, Pavoine C, Zimmer A, Pecker F, Mallat A, Lotersztajn S. (2011). Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice. Hepatology, 54(4):1217-26.
Sigel E, Baur R, Rácz I, Marazzi J, Smart T, Zimmer A, Gertsch J. (2011). The major central endocannabinoid directly acts at GABAA receptors. Proc Natl Acad Sci U S A, 108(44):18150-5.
Jeub M, Emrich M, Pradier B, Taha O, Gailus-Durner V, Fuchs H, de Angelis MH, Huylebroeck D, Zimmer A, Beck H, Racz I. (2011). The transcription factor Smad-interacting protein 1 controls pain sensitivity via modulation of DRG neuron excitability. Pain, 152(10):2384-98.
Dastig S, Nenicu A, Otte DM, Zimmer A, Seitz J, Baumgart-Vogt E, Lüers GH. (2011). Germ cells of male mice express genes for peroxisomal metabolic pathways implicated in the regulation of spermatogenesis and the protection against oxidative stress. Histochem Cell Biol, 136(4):413-25.
Hoyer FF, Steinmetz M, Zimmer S, Becker A, Lütjohann D, Buchalla R, Zimmer A, Nickenig G. (2011). Atheroprotection via cannabinoid receptor-2 is mediated by circulating and vascular cells in vivo. J Mol Cell Cardiol, 51(6):1007-14.
Holl D, Kuckenberg P, Woynecki T, Egert A, Becker A, Huss S, Stabenow D, Zimmer A, Knolle P, Tolba R, Fischer HP, Schorle H. (2011). Transgenic overexpression of Tcfap2c/AP-2gamma results in liver failure and intestinal dysplasia. PLoS One, 6(7):e22034.
Albayram O, Alferink J, Pitsch J, Piyanova A, Neitzert K, Poppensieker K, Mauer D, Michel K, Legler A, Becker A, Monory K, Lutz B, Zimmer A, Bilkei-Gorzo A. (2011). Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging. Proc Natl Acad Sci U S A, 108(27):11256-61.
Trebicka J, Racz I, Siegmund SV, Cara E, Granzow M, Schierwagen R, Klein S, Wojtalla A, Hennenberg M, Huss S, Fischer HP, Heller J, Zimmer A, Sauerbruch T. (2011). Role of cannabinoid receptors in alcoholic hepatic injury: steatosis and fibrogenesis are increased in CB(2) receptor-deficient mice and decreased in CB(1) receptor knockouts. Liver Int., 31(6):862-72. doi: 10.1111/j.1478-3231.2011.02496.x.
Otte DM, Sommersberg B, Kudin A, Guerrero C, Albayram Ö, Filiou MD, Frisch P, Yilmaz Ö, Drews E, Turck CW, Bilkei-Gorzó A, Kunz WS, Beck H and Zimmer A. (2011). N-acetyl cysteine treatment rescues cognitive deficits induced by mitochondrial dysfunction in G72/G30 transgenic mice. Neuropsychopharmacology, 36(11):2233-43.
Braun A, Engel T, Aguilar-Pimentel JA, Zimmer A, Jakob T, Behrendt H, Mempel M. (2011). Beneficial effects of cannabinoids (CB) in a murine model of allergen-induced airway inflammation: Role of CB(1)/CB(2) receptors. Immunobiology, 15;412(2):134-40.
Cichon S, Mühleisen TW, Degenhardt FA, Mattheisen M, Miró X, Strohmaier J, Steffens M, Meesters C, Herms S, Weingarten M, Priebe L, Haenisch B, Alexander M, Vollmer J, Breuer R, Schmäl C, Tessmann P, Moebus S, Wichmann HE, Schreiber S, Müller-Myhsok B, Lucae S, Jamain S, Leboyer M, Bellivier F, Etain B, Henry C, Kahn JP, Heath S; Bipolar Disorder Genome Study (BiGS) Consortium, Hamshere M, O'Donovan MC, Owen MJ, Craddock N, Schwarz M, Vedder H, Kammerer-Ciernioch J, Reif A, Sasse J, Bauer M, Hautzinger M, Wright A, Mitchell PB, Schofield PR, Montgomery GW, Medland SE, Gordon SD, Martin NG, Gustafsson O, Andreassen O, Djurovic S, Sigurdsson E, Steinberg S, Stefansson H, Stefansson K, Kapur-Pojskic L, Oruc L, Rivas F, Mayoral F, Chuchalin A, Babadjanova G, Tiganov AS, Pantelejeva G, Abramova LI, Grigoroiu-Serbanescu M, Diaconu CC, Czerski PM, Hauser J, Zimmer A, Lathrop M, Schulze TG, Wienker TF, Schumacher J, Maier W, Propping P, Rietschel M, Nöthen MM. (2011). Genome-wide Association Study Identifies Genetic Variation in Neurocan as a Susceptibility Factor for Bipolar Disorder. Am J Hum Genet., 88(3):372-81.
Specht S*, Frank JK*, Alferink J, Dubben B, Layland LE, Denece G, Bain O, Förster I, Kirschning CJ, Martin C, Hoerauf A. (2011). CCL17 controls mast cells for the defense against filarial larval entry. J Immunol., 186(8):4845-52. *equal contribution
Schicho R, Bashashati M, Bawa M, McHugh D, Saur D, Hu HM, Zimmer A, Lutz B, Mackie K, Bradshaw HB, McCafferty DM, Sharkey KA, Storr M. (2011). The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment. Inflamm Bowel Dis, 17(8):1651-64.
Horsch M, Seeburg PH, Adler T, Aguilar-Pimentel JA, Becker L, Calzada-Wack J, Garrett L, Götz A, Hans W, Higuchi M, Hölter SM, Naton B, Prehn C, Puk O, Rácz I, Rathkolb B, Rozman J, Schrewe A, Adamski J, Busch DH, Esposito I, Graw J, Ivandic B, Klingenspor M, Klopstock T, Mempel M, Ollert M, Schulz H, Wolf E, Wurst W, Zimmer A, Gailus-Durner V, Fuchs H, de Angelis MH, Beckers J. (2011). Requirement of the RNA-editing Enzyme ADAR2 for Normal Physiology in Mice. J Biol Chem., 286(21):18614-22.
Kuckenberg P, Peitz M, Kubaczka C, Becker A, Egert A, Wardelmann E, Zimmer A, Brüstle O, Schorle H. (2011) Lineage Conversion of Murine Extraembryonic Trophoblast Stem Cells to Pluripotent Stem Cells. Mol Cell Biol., 31(8):1748-56.
Quinn JP, Kipar A, Hughes DJ, Bennett E, Cox H, McLaughlin L, Zimmer A, Hunt SP, StewartJP. (2011). Altered host response to murine gammaherpesvirus 68 infection in mice lacking the tachykinin 1 gene and the receptor for substance P. Neuropeptides, 45: 49-53.
Fuchs H, Durner VG, Adler T, Aguilar-Pimentel JA, Becker L, Calzada-Wack J, Da Silva-Buttkus P, Neff F, Götz A, Hans W, Hölter SM, Horsch M, Kastenmüller G, Kemter E, Lengger C, Maier H, Matloka M, Möller G, Naton B, Prehn C, Puk O, Rácz I, Rathkolb B, Römisch-Marg W, Rozman J, Wang-Sattler R, Schrewe A, Stöger C, Tost M, Adamski J, Aigner B, Beckers J, Behrendt H, Busch DH, Esposito I, Graw J, Illig T, Ivandic B, Klingenspor M, Klopstock T, Kremmer E, Mempe M, Neschen S, Ollert M, Schulz H, Suhre K, Wolf E, Wurst W, Zimmer A, de Angelis MH. (2011). Mouse Phenotyping. Methods: available online.
Kosel M, Bilkei-Gorzo A, Zawatzky R, Zimmer A, Schlaepfer TE. (2011). Pegylated human interferon alpha 2a does not induce depression-associated changes in mice. Psychiatry Res., 185(1-2):243-7.
Ofek O, Attar-Namdar M, Kram V, Dvir-Ginzberg M, Mechoulam R, Zimmer A, Frenkel B, Shohami E, Bab I. (2010). CB2 cannabinoid receptor targets mitogenic Gi protein - cyclin D1 axis in osteoblasts. J Bone Miner Res., 26(2):308-316.
2010
Drews E, Racz I, Lacava AD, Barth A, Bilkei-Gorzo A, Wienker TF, Zimmer A. (2010). Quantitative trait loci contributing to physiological and behavioral ethanol responses after acute and chronic treatment. Int. J. Neuropsychopharmacol., 13(2):155-69.
Petrosino S, Cristino L, Karsak M, Gaffal E, Ueda N, Tüting T, Bisogno T, De Filippis D, D’Amico A, Saturnino C, Orlando P, Zimmer A, Iuvone T, Di Marzo V. (2010). Protective role of palmitoylethanolamide in contact allergic dermatitis. Allergy, 65:698-711.
Murikinati S, Jüttler E, Keinert T, Ridder DA, Muhammad S, Waibler Z, Ledent C, Zimmer A, Kalinke U, Schwaninger M. (2010). Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neurophil recruitment. FASEB J., 24(3):788-98.
Rosemann M, Ivashkevich A, Favor J, Dalke C, Hölter SM, Becker L, Rácz I, Bolle I, Klempt M, Rathkolb B, Kalaydjiev S, Adler T, Aguilar A, Hans W, Horsch M, Rozman J, Calzada-Wack J2, Kunder S, Gailus-Durner V, Fuchs H, Naton B, Schulz H, Beckers J, Busch DH, Burbach JPH, Smidt MP, Quintanilla-Martinez L, Esposito I, Klopstock T, Klingenspor M, Ollert M, Wolf E, Wurst W, Zimmer A, Hrabé de Angelis M, Atkinson M, Heinzmann U, Graw J. (2010). Microphthalmia, Parkinsonism and Enhanced Nociception in Pitx3416insG Mice. Mamm. Genome, 21(1-2):13-27.
Touriño C, Zimmer A, Valverde O. (2010). THC prevents MDMA-induced neurotoxicity in mice. PLoS ONE, 5(2): e9143.
Lim S, Janzer A, Becker A, Zimmer A, Schüle R, Buettner R, Kirfel J. (2010). Lysine-Specific Demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology. Carcinogenesis, 31: 512-520.
Patsch C, Peitz M, Otte DM, Kesseler D, Jungverdorben J, Wunderlich FT, Brüstle O, Zimmer A, Edenhofer F. (2010). Engineering cell-permeant FLP recombinase for tightly controlled inducible and reversible overexpression in embryonic stem cells. Stem Cells, 28(5):894-902.
Frisch P, Bilkei-Gorzó A, Rácz I, Zimmer A. (2010). Modulation of the CRH-system by Substance P / NKA in an animal model of depression. Behav. Brain. Res., 213(1): 103-108.
Agudo J, Martin M, Roca C, Molas M, Bura AS, Zimmer A, Bosch F, Maldonado R. (2010). Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age. Diabetologia, 53(12):2629-40.
Becker A, Bilkei-Gorzo A, Michel K, Zimmer A. (2010) Exposure of mice to long-light: a new animal model to study depression. Eur Neuropsychopharmacol, 20(11):802-12.
Cluny NL, Vemuri VK, Chambers AP, Limebeer CL, Bedard H, Wood JT, Lutz B, Zimmer A, Parker LA, Makriyannis A, Sharkey KA. (2010). A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents. Br. J. Pharmacol., 161(3):629-42.
Tiyerili V, Zimmer S, Jung S, Wassmann K, Naehle CP, Lütjohann D, Zimmer A, Nickenig G, Wassmann S. (2010). CB(1) receptor inhibition leads to decreased vascular AT1 receptor expression, inhibition of oxidative stress and improved endothelial function. Basic Res Cardiol., 105(4):465-77.
Teixeira-Clerc F, Belot M-P, Manin S, Deveaux V, Zimmer A, Tordjmann T, Mallat A, Lotersztajn S. (2010). Beneficial paracrine effects of cannabinoid receptor 2 on liver injury and regeneration. Hepatology, 52(3):1046-59.
Servettaz A, Kavian N, Nicco C, Deveaux V, Chéreau C, Wang A, Zimmer A, Lotersztajn S, Weill B, Batteux F. (2010). Targeting the cannabinoid pathway limits the development of fibrosis and autoimmunity in a mouse model of systemic sclerosis. Am J Pathol. 177(1):187-96.
Helyes Z, Elekes K, Sándor K, Szitter I, Kereskai L, Pintér E, Kemény A, Szolcsányi J, McLaughlin L, Vasiliou S, Kipar A, Zimmer A, Hunt SP, Stewart JP, Quinn JP. (2010). Involvement of preprotachykinin A gene-encoded peptides and the neurokinin 1 receptor in endotoxin-induced murine airway inflammation. Neuropeptides, 44 (2010) 399-406.
Bilkei-Gorzo A, Berner J, Zimmermann J, Wickström R, Racz I, Zimmer A. (2010). Increased morphine analgesia and reduced side effects in mice lacking the tac1 gene. Br J Pharmacol., 160(6): 1443-1452.
Bilkei-Gorzo A, Drews E, Albayram O, Piyanova A, Gaffal E, Tueting T, Michel K, Mauer D, Maier W, Zimmer A. (2010). Early onset of aging-like changes is restricted to cognitive abilities and skin structure in Cnr1-/- mice. Neurobiol Aging, doi:10.1016/j.neurobiolaging.
Rietschel M, Mattheisen M, Frank J, Treutlein J, Degenhardt F, Breuer R, Steffens M, Mier D, Esslinger C, Walter H, Kirsch P, Erk S, Schnell K, Herms S, Wichmann HE, Schreiber S, Jöckel KH, Strohmaier J, Roeske D, Haenisch B, Gross M, Hoefels S, Lucae S, Binder EB, Wienker TF, Schulze TG, Schmäl C, Zimmer A, Juraeva D, Brors B, Bettecken T, Meyer-Lindenberg A, Müller-Myhsok B, Maier W, Nöthen MM, Cichon S. (2010). Genome-Wide Association-, Replication-, and Neuroimaging Study Implicates HOMER1 in the Etiology of Major Depression. Biol. Psychiatry, 68(6):578-85.
Drews E, Zimmer A. (2010). Modulation of alcohol and nicotine responses through the endogenous opioid system. Prog. Neurobiol., 90(1): 1-15.
Braun A, Engel T, Aguilar-Pimentel JA, Zimmer A, Jakob T, Behrendt H, Mempel M. (2010). Beneficial effects of cannabinoids (CB) in a murine model of allergen-induced airway inflammation: Role of CB(1)/CB(2) receptors. Immunobiology, 412(2):134-40.
Spanagel R, Bartsch D, Brors B, Dahmen N, Deussing J, Eils R, Ende G, Gallinat J, Gebicke-Haerter P, Heinz A, Kiefer F, Jäger W, Mann K, Matthäus F, Nöthen M, Rietschel M, Sartorius A, Schütz G, Sommer WH, Sprengel R, Walter H, Wichmann E, Wienker T, Wurst W, Zimmer A. (2010). An integrated genome research network for studying the genetics of alcohol addiction. Addict Biol. 15(4):369-79. doi: 10.1111/j.1369-1600.2010.00276.x.
Beer-Hammer S, Zebedin E, von Holleben M, Alferink J, Reis B, Dresing P, Degrandi D, Scheu S, Hirsch E, Sexl V, Pfeffer K, Nürnberg B, Piekorz RP. (2010). The catalytic PI3K isoforms p110{gamma} and p110{delta} contribute to B cell development and maintenance, transformation, and proliferation. J Leukoc Biol., available online
Onur OA, Kukolja J, Bauer A, Patin A, Otte DM, Jeung H, Jon Shah N, Maier W, Fink GR, Hurlemann R. (2010). The N-methyl-D-aspartate receptor co-agonist D-cycloserine facilitates declarative learning and hippocampal activity in humans, Biol Psychiatry, 67(12):1205-11
Fuchs A, Ringer C, Bilkei-Gorzo A, Weihe E, Roeper J, Schütz B. (2010). Downregulation of the potassium chloride cotransporter KCC2 in vulnerable motoneurons in the SOD1-G93A mouse model of amyotrophic lateral sclerosis. J Neuropathol Exp Neurol., 69(10):1057-70.
Shvarev Y, Berner J, Bilkei-Gorzo A, Lagercrantz H, Wickström R. (2010). Acute morphine effects on respiratory activity in mice with target deletion of the tachykinin 1 gene (Tac1-/-). Adv Exp Med Biol., 669:129-32.
2009
Akhmetshina A, Dees C, Busch N, Beer J, Zimmer A, Distler O, Schett G, Distler JHW. (2009). The cannabinoid receptor CB2 exerts anti-fibrotic effects in experimental dermal fibrosis. Arth. Rheum., 60:1129-1136.
Glassmann A, Topka S, Wang-Eckardt L, Anders S, Weisheit G, Zimmer A, Schilling K. (2009). Basic molecular fingerprinting of immature cerebellar cortival inhibitory interneurons and their precursors. Neuroscience, 159: 69-82.
Otte DM, Bilkei-Gorzó A, Filiou MD, Turck CW, Yilmaz Ö, Holst MI, Schilling K, Abou-Jamra R, Schumacher J, Benzel I, Kunz WS, Beck H, Zimmer A. (2009). Behavioral changes in G72/G30 transgenic mice. Eur. Neuropsychopharm., 19: 339-348.
Defer N, Wan J, Souktani R, Escoubet B, Perier M, Caramelle P, Manin S, Deveaux V, Bourin MC, Zimmer A, Lotersztajn S, Pecker F, Pavoine C. (2009). The cannabinoid receptor type 2 promotes cardiac myocyte and fibroblast survival and protects against ischemia/reperfusion-induced cardiomyopathy. FASEB J., 23: 2120-2130.
Enard W, Gehre S, Hammerschmidt K, Hölter SM, Blass T, Somel M, Bruckner MK, Schreiweis C, Winter C, Sohr R, Becker L, Wiebe V, Nickel B, Giger T, Muller U, Groszer M, Adler T, Aguilar A, Bolle I, Calzada-Wack J, Dalke C, Ehrhardt N, Favor J, Fuchs H, Gailus-Durner V, Hans W, Hölzlwimmer G, Javaheri A, Kalaydjiev S, Kallnik M, Kling E, Kunder S, Moßbrugger I, Naton B, Racz I, Rathkolb B, Rozman J, Schrewe8 A, Busch DH, Graw J, Ivandic B, Klingenspor M, Klopstock T, Ollert M, Quintanilla-Martinez L, Schulz H, Wolf E, Wurst W, Zimmer A, Fisher SE, Morgenstern R, Arendt T, Hrabé de Angelis M, Fischer J, Schwarz J, Pääbo S. (2009). A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell, 137: 961-971.
Darvas M, Morsch M, Racz I, Ahmadi S, Swandulla D, Zimmer A. (2009). Modulation of the Ca2+ Conductance of Nicotinic Acetylcholine Receptors by Lypd6. Europ. Neuropsychopharm., 19: 670-681.
Nyilas R, Gregg LC, Mackie K, Watanabe M, Zimmer A, Hohmann AG and Katona I. (2009). Molecular architecture of endocannabinoid signaling at nociceptive synapses mediating analgesia. Eur. J. Neurosci., 29: 1964-1978.
Trigo JM, Zimmer A, Maldonado R. (2009). Nicotine anxiogenic and rewarding effects are decreased in mice lacking ß-endorphin. Neuropharmacology, 56: 1147-1153.
Deveaux V, Cadoudal T, Ichigotani Y, Teixeira-Clerc F, Louvet A, Manin S, Nhieu JT, Belot MP, Zimmer A, Even P, Cani PD, Knauf C, Burcelin R, Bertola A, Le Marchand-Brustel Y, Gual P, Mallat A, Lotersztajn S. (2009). Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis. PLoS ONE. 2009 Jun 9;4(6):e5844.
Karsak M, Malkin I, Toliat MR, Kubisch C, Nürnberg P, Zimmer A, Livshits G. (2009). The cannabinoid receptor type 2 (CNR2) gene is associated with hand bone strength phenotypes in an ethnically homogeneous family sample. Hum. Genet., 126(5): 629-36.
Wirth EK, Roth S, Blechschmidt C, Holter SM, Becker L, Racz I, Zimmer A, Klopstock T, Gailus-Durner V, Fuchs H, Wurst W, Naumann T, Brauer A, de Angelis MH, Kohrle J, Gruters A, Schweizer U. (2009). Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome. J. Neurosci., 29:9439-9449.
Crombag HS, Johnson AW, Zimmer AM, Zimmer A, Holland PC. (2009). Deficits in sensory-specific devaluation task performance following genetic deletions of cannabinoid (CB1) receptor. Learn Mem., 17(1):18-22.
Fuchs H, Gailus-Durner V, Adler T, Pimentel JA, Becker L, Bolle I, Brielmeier M, Calzada-Wack J, Dalke C, Ehrhardt N, Fasnacht N, Ferwagner B, Frischmann U, Hans W, Holter SM, Holzlwimmer G, Horsch M, Javaheri A, Kallnik M, Kling E, Lengger C, Maier H, Mossbrugger I, Morth C, Naton B, Noth U, Pasche B, Prehn C, Przemeck G, Puk O, Racz I, Rathkolb B, Rozman J, Schable K, Schreiner R, Schrewe A, Sina C, Steinkamp R, Thiele F, Willershauser M, Zeh R, Adamski J, Busch DH, Beckers J, Behrendt H, Daniel H, Esposito I, Favor J, Graw J, Heldmaier G, Hofler H, Ivandic B, Katus H, Klingenspor M, Klopstock T, Lengeling A, Mempel M, Muller W, Neschen S, Ollert M, Quintanilla-Martinez L, Rosenstiel P, Schmidt J, Schreiber S, Schughart K, Schulz H, Wolf E, Wurst W, Zimmer A, Hrabe de Angelis M. (2009) The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models. Curr. Pharm. Biotechno. 10:236-243.
Bab I, Zimmer A, Melamed E. (2009). Cannabinoids and the skeleton: From marijuana to reversal of bone loss. Ann. Med., 41(8):560-7.
Drews E, Zimmer A. (2009). Central sensitization needs sigma receptors. Pain, 145:269-270.
Klotz L, Burgdorf S, Dani I, Saijo K, Flossdorf J, Hucke S, Alferink J, Novak N, Beyer M, Mayer G, Langhans B, Klockgether T, Waisman A, Eberl G, Schultze J, Famulok M, Kolanus W, Glass C, Kurts C, Knolle PA. (2009). The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity. J Exp Med., 206(10):2079-89.
Haenisch B, Bilkei-Gorzó A, Caron MG, Bönisch H. (2009) Knockout of the norepinephrine transporter and pharmacologically diverse antidepressants prevent behavioral and brain neurotrophin alterations in two chronic stress models of depression. J. Neurochem, 111(2):403-416.
Kölsch H, Wagner M, Bilkei-Gorzó A, Toliat MR, Pentzek M, Fuchs A, Kaduszkiewicz H, van den Bussche H, Riedel-Heller SG, Angermeyer MC, Weyerer S, Werle J, Bickel H, Mösch E, Wiese B, Daerr M, Jessen F, Maier W, Dichgans M. Gene polymorphisms in prodynorphin (PDYN) are associated with episodic memory in the elderly. J Neural Transm, 2009, 116(7):897-903.
2008
Nenicu A, Luers GH, Kovacs W, Otte D, Zimmer A, Bergmann M, Baumgart-Vogt E. (2008). Peroxisomes in human and mouse testis: Differential expression of peroxisomal proteins in germ cells and distinct somatic cell types of the testis. Biol. Reprod. 77: 1060-1072.
Mátyás F, Urbán GM, Watanabe M, Mackie K, Zimmer A, Freund TF, Katona I. (2008). Identification of the sites of 2-arachidonoylglycerol synthesis and action imply retrograde endocannabinoid signaling at both GABAergic and glutamatergic synapses in the ventral tegmental area. Neuropharmacology, 54: 95-107.
Tam J, Trembovler V, Di Marzo V, Petrosino S, Leo G, Alexandrovich A, Regev E, Casap N, Shteyer A, Ledent C, Karsak M, Zimmer A, Mechoulam R, Yirmiya R, Shohami E, Bab I (2008). The Cannabinoid CB1 Receptor Regulates Bone Formation by Modulating Adrenergic Signaling. FASEB J., 22: 285-294.
Bilkei-Gorzo A, Racz I, Michel K, Darvas M, Maldonado R, Zimmer A. (2008). A common genetic predisposition to stress-sensitivity and stress-induced nicotine craving. Biol. Psychiatry, 63: 164-171. Epub Jun 13, 2007.
Bilkei-Gorzo A, Otto M, Zimmer A. (2008). Environmental modulation of anxiety-related neuronal activity and behaviours. Behav. Brain Res., 186: 289-292.
Noble F, Benturquia N, Bilkei-Gorzo A, Zimmer A, Roques BP. (2008). Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours. Psychopharmacology, 196: 327-335. Epub Oct 1, 2007.
Jones S, Tucker KL, Sage T, Kaiser WJ, Barrett NE, Lowry PJ, Zimmer A, Hunt SP, Emerson M, Gibbins JM. (2008). Peripheral tachykinins and the neurokinin receoptor NK1 are required for platelet thrombus formation. Blood, 111: 605-612. Epub Sept 25, 2007.
Suarez J, Bermudez-Silva FJ, Mackie K, Ledent C, Zimmer A, Cravatt BF, de Fonseca FR. (2008). Immunohistochemical description of the endogenous cannabinoid system in the rat cerebellum and functionally related nuclei. J. Comp. Neurol., 509: 400-421.
Bilkei-Gorzo A, Racz I, Michel K, Mauer D, Zimmer AM, Klingmuller D, Zimmer A. (2008). Control of hormonal stress reactivity by the endogenous opioid system. Psychoneuroendocrinology, 33: 425-436.
Bilkei-Gorzo A, Abo-Salem OM, Hayallah AM, Michel K, Muller CE, Zimmer A. (2008). Adenosine receptor subtype-selective antagonists in inflammation and hyperalgesia. Naunyn-Schmiedeberg's Arch. Pharmacol., 377: 65-76.
Gertsch J, Leonti M, Raduner S, Racz I, Chen JZ, Xie XQ, Altmann KH, Karsak M, Zimmer A. (2008). Beta-carophyllene is a diatary cannabinoid. Proc. Natl. Acad. Sci. USA, 26: 9099-9104.
Racz I, Schurmann B, Karpushova A, Reuter M, Cichon S, Montag C, Furst R, Schuetz C, Franke PE, Strohmaier J, Wienker TF, Terenius L, Osby U, Gunnar A, Maier W, Bilkei-Gorzo A, Nothen M, Zimmer A. (2008). The opioid peptides enkephalin and beta-endorphin in alcohol dependence. Biol. Psychiatry, 64: 989-997.
Racz I, Bilkei-Gorzo A, Markert A, Stamer F, Gothert M, Zimmer A. (2008) Anandamide effects on 5-HT3 receptors in vivo. Europ. J. Pharmacol., 596: 98-101.
Grote A, Boldogkoi Z, Hans M, Zimmer A, Steinhauser C., Jabs R. (2008). Nanomolar ambient ATP decelerates P2X3 receptor kinetics. Neuropharmacology, 55: 1212-1218.
Paldy E, Bereczki E, Santha M, Wenger T, Borsodi A, Zimmer A, Benyhi, S. (2008) CB2 cannabinoid receptor antagonist SR144528 decreases mu-opioid receptor expression and activation in mouse brainstem: role of CB2 receptor in pain. Neurochem. Int., 53: 309-316.
Galeote L, Berrendero F, Bura SA, Zimmer A, Maldonado R. (2008) Prodynorphin gene disruption increases the sensitivity to nicotine self-administration in mice. Int. J. Neuropsychoph., 12:615-625.
Racz I, Nadal X, Alferink J, Banos JE, Rehnelt J, Martin M, Pintado B, Gutierrez-Adan A, Sanguino E, Manzanares J, Zimmer A#, Maldonado R. (2008). Crucial role of CB2 cannabinoid receptor in the regulation of central immune responses during neuropathic pain. J.Neurosci., 28: 12125-12135. #corresponding author.
Racz I, Nadal X, Alferink J, Banos JE, Rehnelt J, Martin JM, Pintado B, Gutierrez-Adan A, Sanguino E, Manzanares J, Bellora N, Zimmer A#, Maldonado R. (2008). Interferon-gamma is a critical modulator of CB2 cannabinoid receptor signaling during neuropathic pain. J.Neurosci., 28: 12136-12145. #corresponding author.
Avraham Y, Zolotarev O, Grigoriadis NC, Pautahidis T, Magen I, Vorobiav L, Zimmer A, Ilan Y, Mechoulam R, Berry E M. (2008) Cannabinoids and capsaicin improve liver function following thioacetamide-induced acute injury in mice. Am J Gastroenterol, 103, 3047-56.
Karsak M, Bab I, Zimmer A. (2008). New insights into the endocannabinoid system by using cannabinoid receptor knockout mice. In: The Cannabinoid Receptors. (ed. P. Reggio), Humana Press.
Lotersztajn S, Teixeira-Clerc F, Julien B, Deveaux V, Ichigotani Y, Manin S, Tran-Van-Nhieu J, Karzak M, Zimmer A, Mallat A. (2008). CB2 receptors as new therapeutic targets during liver diseases. Br. J. Pharm., 153: 286-289.
Bab I, Ofek O, Tam J, Rehnelt J, Zimmer A. (2008). Endocannabinoids and the regulation of bone metabolism. J. Neuroendocrinol., Suppl. 1: 69-74.
Drews E, Becker A, Bilkei-Gorzo A, Zimmer A. (2008) Animal models of affective behaviors and drug addiction. In:Biomarkers for Psychiatric Disorders. (ed. C.W. Turck). 217-234.
2007
Bilkei-Gorzo A, Michel K, Noble F, Roques BP, Zimmer A. (2007). Preproenkephalin knockout mice show no depression-related phenotype. Neuropsychopharmacology, 32: 2330-2337.
Bailey A, Yoo JH, Rácz I, Zimmer A, Kitchen I. (2007). Preprodynorphin mediates locomotion and D2 dopamine and mu- opioid receptor changes induced by chronic “binge” cocaine administration. J. Neurochem, 102: 1817-1830.
Karsak M, Gaffal E, Date R, Wang-Eckhardt L, Rehnelt J, Petrosino S, Starowicz K, Steuder R, Schlicker E, Cravatt B, Mechoulam R, Buettner R, Werner S, Di Marzo V, Tuting T, Zimmer A. (2007). Attenuation of allergic contact dermatitis through the endocannabinoid system. Science, 316: 1494-1497.
Mazzuca M, Heurteaux C, Alloui A, Diochot S, Baron A, Voilley N, Blondeau N, Gélot A, Cupo A, Zimmer A, Zimmer AM, Eschalier A, Lazdunski M. (2007). A tarantula peptide against pain via ASIC1a channels and opioid mechanisms. Nat. Neurosci., 10: 943-945.
Bab I, Zimmer A. (2007). Cannabinoid receptors and the regulation of bone mass. Br. J. Pharm., 153: 182-188.
Schürmann B, Rácz I, Zimmer A. (2007). Tierexperimentelle Untersuchungen zur Funktion des endogenen Opioidsystems bei der Modulation von Suchtverhalten. Nervenheilkunde. 26: 897-901.
Karsak M, Zimmer A. (2007). Cannabinoide im Einsatz bei Allergien. BIOforum, 5: 52-53.
Berner J, Shvarev Y, Lagercrantz H, Bilkei-Gorzo A, Hškfelt T, Wickstršm R (2007). Altered respiratory pattern and hypoxic response in transgenic newborn mice lacking the tachykinin-1 gene. J.Appl.Physiol., 103 (2): 552-559
2006
Mendizábal V, Zimmer A, Maldonado R. (2006). Involvement of kappa/dynorphin system in WIN 55,212-2 self-administration in mice. Neuropharmacology, 31: 1957-1966.
Duarte C, Schütz B, Zimmer A. (2006). Incongruent pattern of neurokinin B expression in rat and mouse brains. Cell Tiss. Res., 323: 43-51.
Ofek O, Karsak M, Leclerc N, Fogel M, Frenkel B, Wright K, Tam J, Attar-Namdar M, Kram V, Shohami E, Mechoulam R, Zimmer A, Bab I. (2006). Peripheral CB2 Cannabinoid Receptor, CB2, Regulates Bone Mass. Proc. Natl. Acad. Sci. USA, 103: 696-701.
Heneka MT, Ramanathan M, Jacobs AH, Dumitrescu-Ozimek L, Bilkei-Gorzo A, Debeir T, Sastre M, Galldiks N, Zimmer A, Hoehn M, Heiss WD, Klockgether T, Staufenbiel M (2006) Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice. J Neurosci. 26:1343-1354.
Tam J, Ofek O, Friede E, Ledent C, Gabet Y, Muller R, Zimmer A, Mackie K, Mechoulam R, Shohami E, Bab I. (2006). Involvement of neuronal cannabinoid receptor CB1 in regulation of bone mass and bone remodeling. Mol. Pharmacol., 70: 786-792.
Racz I, Zimmer A. (2006) Animal models in nociception. In: Standards of Mouse Phenotyping (ed. Hrabé de Angelis, Chambon, Brown).
2005
Berrendero F, Mendizábal V, Robledo P, Galeote L, Bilkei-Gorzo A, Zimmer A, Maldonado R (2005). Nicotine-induced antinociception, rewarding effects, and physical dependence are decreased in mice lacking the preproenkephalin gene. J.Neurosci., 25: 1103-1112.
Julien B, Grenard P, Teixeira-Clerc F, Van Nhieu JT, Li L, Karsak M, Zimmer A, Mallat A, Lotersztajn S. (2005). Antifibrogenic role of the cannabinoid receptor CB2 in the liver. Gastroenterology, 128: 742-755.
Steffens S, Veillard NR, Arnaud C, Pelli G, Burger F, Staub C, Karsak M, Zimmer A, Frossard JL, Mach F. (2005). Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice. Nature 434: 782-786.
Gailus-Durner V, Fuchs H, Becker L, Bolle I, Brielmeier M, Calzada-Wack J, Elvert R, Ehrhardt N, Dalke C, Franz TJ, Grundner-Culemann E, Hammelbacher S, Hölter SM, Hölzlwimmer G, Horsch M, Javaheri A, Kalaydjiev S, Klempt M, Kling E, Kunder S, Lengger C, Lisse T, Mijalski T, Naton B, Pedersen V, Prehn C, Przemeck G, Racz I, Reinhard C, Reitmeir P, Schneider I, Schrewe A, Steinkamp R, Zybill C, Adamski J, Beckers J, Behrendt H, Favor J, Graw J, Heldmaier G, Höfler H, Ivandic B, Katus H, Kirchhof P, Klingenspor M, Klopstock T, Lengeling A, Müller W, Ohl F, Ollert M, Quintanilla-Martinez L, Schmidt J, Schulz H, Wolf E, Wurst W, Zimmer A, Busch DH, Hrabé de Angelis M. (2005). Introducing the German Mouse Clinic: Open access platform for standardized phenotyping. Nat. Methods, 2: 403-404.
Schütz B, Reimann J, Dumitrescu-Ozimek L., Schürmann B, Kappes-Horn K, Landreth GE, Zimmer A, Heneka MT. (2005). The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A tansgenic mice. J.Neurosci., 25: 7805-7812.
The FANTOM Consortium, Riken Genome Science Laboratory and Riken Genome Exploration Research Group. (FANTOM Consortium: Carninci P, Kasukawa T, Katayama S, Gough J, Frith M, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest ARR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen J, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Basal M, Beisel KW, Bersano T, Bono H, Bradt D, Chiu KP, Chalk A, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, McWilliam S, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Hallinan J, Harbers M, Harokopos V, Hatanaka K, Hayashi Y, Henning S, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SPT, Kruger A, Kummerfeld S, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Mohan M, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, van Nimwegene E, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Qi D, Qu W, Reed J, Reid J, Ring BZ, Ringwald M, Rost B, Ruan Y, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CAM, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann S, Ueda HR, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick J, Hume D; RIKEN Genome Exploration Research Group: Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori M, Suzuki M, Aoki J, Arakawa T, Hori F, Hirakiyama A, Iida J, Imamura K, Imotani K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Murakami K, Nakano K, Ninomiya N, Nishio T, Nishiyori H, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Tsujimura Y, Waki K, Watahiki A, Oho Y, Suzuki H, Kawai J, Hayashizaki Y. (2005). The transcriptional landscape of the mammalian genome. Science, 309: 1559-1563.
Bilkei-Gorzo A, Racz I, Valverde O, Otto M, Michel K, Sarstre M, Zimmer A. (2005). Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors. Proc. Natl. Acad. Sci. USA, 102: 15670-15675.
Karsak M, Cohen-Solal M, Freudenberg J, Ostertag A, Morieux C, Kornak U, Essig J, Erxlebe E, Bab I, Kubisch C, de Vernejoul MC, Zimmer A. (2005). Cannabinoid receptor type 2 gene is associated with human osteoporosis. Mol. Human Genet., 14: 3389-3396.
Guan JS, XU ZZ, Gao H, He SQ, Ma GQ, Sun T, Wang LH, Zhang ZN, Lena I, Kitchen I, Elde R, Zimmer A, He C, Pei G, Bao L, Zhang X. (2005). Interaction with vesicle luminal Protachykinin regulates surface expression of delta-opioid receptors and opioid analgesia. Cell 122: 619-631.
Rodd ZA, Anstrom KK, Knapp DJ, Racz I, Zimmer A, Serra S, Bell RL, Woodward DJ, Breese GR, Colombo G. (2005). Factors mediating alcohol craving and relapse: Stress, compulsivity, and genetics. Alcohol Clin. Exp. Res., 29: 1325-1333.
Grote A, Boldogkoi Z, Zimmer A, Steinhäuser C, Jabs R. (2005). Functional characterization of P2X(3) receptors fused with fluorescent proteins. Mol. Membrane Biol., 22: 497-506.
Racz I, Schütz B, Abo-Salem O, Zimmer A. (2005). Visceral, inflammatory and neuropathic pain in glycine receptor alpha 3-deficient mice. Neuroreport, 16: 2025-2028.
Valverde O, Karsak M, Zimmer A. (2005). Analysis of the endocannabinoid system by using CB1 cannabinoid receptor knockout mice. Handbook of Pharmacology, 168: 115-142.
Bilkei-Gorzo A, Zimmer A. (2005). Mutagenesis and knockout models: NK1 and substance P. Handbook of Pharmacology, 169: 143-162.
2004
Abo-Salem OM, Hayallah AM, Bilkei-Gorzo A, Filipek B, Zimmer A#, Müller CE. (2004). Anticociceptive effects of novel A2B adenosine receptor antagonists, JPET, 308: 358-366 #corresponding author.
Schütz B, Mauer D, Salmon AM, Changeux JP, Zimmer A. (2004). Analysis of the cellular expression pattern of beta-CGRP in alpha-CGRP-deficient mice. J. Comp. Neurol. 476: 32-43.
Pritchard C, Hayes L, Wojnowski L, Zimmer A, Marais R, Norman J (2004). B-raf acts via ROCKII/LIMK/cofilin pathway to maintain actin stress fibres in fibroblasts. MCB, 24: 5937-5952.
Bilkei-Gorzo A, Michel K, Zimmer AM, Klingmüller D, Zimmer A. (2004). Behavioral phenotype of pre-proenkephalin-deficient mice on diverse congenic backgrounds. Psychopharmacology, 176: 343-352.
Harvey RJ, Depner UB, Wässle H, Ahmadi S, Heindl C, Reinold H, Smart TG, Harvey K, Schütz B, Abo-Salem O, Zimmer A, Poisbeau P, Welzl H, Wolfer DP, Betz H, Zeilhofer HU, Müller U (2004). GlyR alpha 3: an Essential Target for Spinal PGE(2)-Mediated Inflammartory Pain Sensitization. Science, 304: 884-887.
Bailey A, Weber D, Zimmer A, Zimmer AM, Hourani SM, Kitchen I. (2004). Quantitative autoradiography of adenosine receptors and NBTI-sensitive adenosine transporters in the brains of mice deficient in the preproenkephalin gene. Brain Res., 1025: 1-9.
2003
Racz I, Bilkei-Gorzo A, Toth ZE, Michel K, Palkovits M, Zimmer A. (2003). A critical role for the cannabinoid CB1 receptors in alcohol dependence and stress-stimulated ethanol drinking. J. Neurosci., 23: 2453-2458.
Wang L, Liu J, Harvey-White J, Zimmer A, Kunos G. (2003). Endocannabinoid signaling via cannabinoid receptor is involved in ethanol preference and its age-dependent decline in mice. Proc. Natl. Acad. Sci. USA., 100: 1393-1398.
Gustincich S, Batalov S, Beisel KW, Bono H, Carninci P, Fletcher CF, Grimmond S, Hirokawa N, Jarvis ED, Jegla T, Kawasawa Y, LeMieux J, Miki H, Raviola E, Teasdale RD, Tominaga N, Yagi K, Zimmer A, Hayashizaki Y, Okazaki Y. (2003) Analysis of the mouse transcriptome for genes involved in the function of the nervous system. Genome Res 13: 1395-1401.
Clarke S, Zimmer A, Zimmer AM, Hill RG, Kitchen I (2003). Region selective up-regulation of the mu-, delta- and kappa-opioid receptor but not opioid receptor-like 1 receptors in the brains of enkephalin and dynorphin knockout mice. Neuroscience, 122: 479-489
Zimmer A. (2003). Maus-Genom entziffert. Biologie in unserer Zeit, 33(2): 78-79.
2002
Yoshida T, Hashimoto K, Zimmer A, Maejima T, Araishi K, Kano M. (2002). The Cannabinoid CB1 Receptor Mediates Retrograde Signals for Depolarization-Induced Suppression of Inhibition in Cerebellar Purkinje Cells. J. Neurosci., 22: 1690-1697.
Ohno-Shosaku T., Tsubokawa H., Mizushima I., Yoneda N., Zimmer A., Kano M. (2002). Presynaptic cannabinoid sensitivity is a major determinant of depolarization-induced retrograde suppression at hippocampal synapses. J. Neurosci., 22: 3864-3872.
Chen CC, Zimmer A., Sun WH, Hall J, Brownstein MJ, Zimmer A. (2002). A role for ASIC3 in the modulation of high-intensity pain stimuli. Proc. Natl. Acad. Sci. USA, 99: 8992-8997.
Boldogköi Z, Schütz B, Sallach J, Zimmer A. (2002) P2X(3) receptor expression at early stages of mouse embryogenesis. Mech. Dev., 118: 255-260.
Bilkei-Gorzo A, Radcz I, Zimmer A. (2002). Diminished Anxiety- and Depression-Related Behaviors in Mice with Selective Deletion of the Tac1 Gene. J. Neurosci., 22: 10046-10052.
The FANTOM Consortium* and The RIKEN Genome Exploration Research Group # (*Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schonbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A) (#Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y). (2002). Analysis of the Mouse Transcriptome based upon Functional Annotation of 60,770 full length cDNAs. Nature, 420: 563-573.
Karsak M, Hrabé de Angelis M., Zimmer A. (2002). Mausmutanten in der Schmerzforschung: Neue Erkenntnisse durch Genmutationen. Biospektrum, 1.02: 17-21
2001
Hopley RL, Zimmer A. (2001). MouseBank: A Database application for managing transgenic mouse breeding programs. BioTechniques, 30: 130-132.
Selley DE, Rorrer WK, Breivogel CS, Zimmer AM, Zimmer A, Martin B, Sim-Selley LJ. (2001). Agonist efficacy and receptor efficiency in heterozygous CB1 knockout mice: Relationship of reduced CB1 receptor density to G-protein activation. J. Neurochem. 77: 1048-1057.
Kathmann M, Weber B, Zimmer A, Schlicker E. (2001) Enhanced acetylcholine release in the hippocampus of cannabinoid CB1 receptor-deficient mice. Br. J. Pharm. 132: 1169-1173.
Paria BC, Song H, Wang X, Schmid PC, Krebsach RJ, Schmid HHO, Bonner TI, Zimmer A, Dey SK. (2001). Dysregulated cannabinoid signaling disrupts uterine receptivity for embryo implantation. J. Biol. Chem. 8: 276: 20523-20528.
Nadeau JH, Balling R, Barsh G, Beier D, Brown DM, Bucan M, Camper S, Carlson G, Copeland N, Eppig J, Fletcher C,Frankel W, Ganten D, Goldowitz D, Goodnow C, Guenet JL, Hicks G, Hrabe de Angelis M, Jackson I, Jenkins N, Johnson D, Justice M, Kay S, Kingsley D, Lehrach H, Magnuson T, Meisler M, Poustka AM, Rinchik G, Rossant J, Russell L, Schimenti J, Shiroishi T, Skarnes B, Soriano P, Stanford B, Takahashi J, Wurst W, Zimmer A (2001). Sequence interpretation - Functional annotation of mouse genome sequences. Science, 291: 1251-1255
Kingery WS, Sawamura S, Agashe GS, Davies MF, Clark JD, Zimmer A. (2001). Enkephalin release and opioid receptor activation does not mediate the antinociceptive or sedative/hypnotic effects of nitrous oxide. Eur. J. Pharm. 427: 27-35.
Zimmer A, Valjent E, König M, Zimmer AM, Clarke S, Robledo P, Chen CC, Hahn H, Valverde O, Hill RG, Kitchen I, Maldonado R. (2001). Absense of delta-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice. J. Neurosci. 21: 9499-9505.
2000
Wojnowski L, Stancato LF, Larner AC, Rapp UR, Zimmer A. (2000). Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis. Mech. Dev., 91:97-104.
Járai Z, Wagner JA, Goparaju SK, Wang L, Razdan RK, Sugiura T, Zimmer AM, TI Bonner, Zimmer A, Kunos G. (2000). Cardiovascular effects of 2-arachidonyl glycerol in anesthetized mice. Hypertension, 35: 679-684.
Buckley NE, McCoy KL, Mezey E, Bonner T, Zimmer AM, Felder CC, Glass M, Zimmer A. (2000). Immunomodulation by Cannabinoids is Absent in Mice Deficient for the Cannabinoid CB2 Receptor. Europ. J. Pharmacol., 396: 141-149.
Hook S, Prout M, Camberis M, Konig M, Zimmer A, Van Heeke G, Le Gros G, (2000). Th2-dependent airway eosinophilia is regulated by preproenkephalin. J. Neuroimmunol 107: 59-65
Hahn H, Wojnowski L, Specht K, Kappler R, Calzada-Wack J, Potter D, Zimmer A, Muller U, Samson E, Quintanilla-Martinez L, and Zimmer A.. 2000. Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma. J. Biol. Chem., 37: 28341-28344.
Hrabe de Angelis MH, Flaswinkel H, Fuchs H, Rathkolb B, Soewarto D, Marschall S, Heffner S, Pargent W, Wuensch K, Jung M, Reis A, Richter T, Alessandrini F, Jakob T, Fuchs E, Kolb H, Kremmer E, Schaeble K, Rollinski B, Roscher A, Peters C, Meitinger T, Strom T, Steckler T, Holsboer F, Klopstock T, Gekeler F, Schindewolf C, Jung T, Avraham K, Behrendt H, Ring J, Zimmer A, Schughart K, Pfeffer K, Wolf E, Balling R. (2000) Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nature Genetics, 25: 444-447.
Di Marzo V, Breivogel CS, Tao Q, Bridgen DT, Razdan RK, Zimmer AM, Zimmer A, Martin BR. (2000). Levels, metabolism, and pharmacological activity of anandamide in CB1 cannabinoid receptor knockout mice: Evidence for non-CB1, non-CB2 receptor-mediated actions of anandamide in mouse brain. J. Neurochem., 75: 2434-2444.
Valverde O, Maldonado R, Valjent E, Zimmer AM, Zimmer A. (2000) Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knockout mice. J. Neurosci., 20: 9284-9289.
Zimmer A, Usdin T. (2000). Examination of the opioid system using targeted gene deletions. In: Molecular Basis of Pain Induction. (ed. J.N. Wood). Wiley-Liss. 193-207.
1999
Steiner H, Bonner T, Zimmer AM, Kitai ST, Zimmer A. (1999). Altered gene expression in striatal projection neurons in CB1 cannabinoid receptor knockout mice. Proc. Natl. Acad. Sci. USA, 96: 5786-5790.
Zimmer A, Zimmer AM, Hohman A, Herkenham M, Bonner T. (1999). Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proc Natl. Acad. Sci. USA, 96: 5780-5785.
Inoue M, Shimohira I, Yoshida A, Zimmer A, Mantyh P, Takeshima H, Sakurada T, Ueda H. (1999). Dose-related opposite modulation by nociceptin/orphanin FQ of substance P nociception in the nociceptors and spinal cord. J. Pharmacol. Exp. Ther., 291: 308-313.
Brady LS, Herkenham M., Rothman RB, Partilla JS, König M., Zimmer AM, Zimmer A. (1999). Region-specific up-regulation of opioid receptor binding in enkephalin knockout mice. Brain Res. Mol. Brain Res., 68: 193-197.
Hook S, Camberis M, Prout M, Konig M, Zimmer A, Heeke GV, Gros GL. (1999). Preproenkephalin is a Th2 cytokine but is not required for Th2 differentiation in vitro. Immunol. Cell Biol., 77: 385-390.
Jarai Z, Wagner JA, Varga K, Lake KD, Compton DR, Martin BR, Zimmer AM, Bonner TI, Buckley NE, Mezey E, Razdan RK, Zimmer A, Kunos G. (1999). Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 and CB2 receptors. Proc. Natl. Acad. Sci. USA, 96: 14136-14141.
Hahn H, Wojnowski L, Miller G, Zimmer A. (1999). The patched signaling pathway in tumorigenesis and development: lessons from animal models. J. Mol. Med., 77: 459-468.
1998
Young WS, 3rd, Shepard E, DeVries AC, Zimmer A, LaMarca ME, Ginns EI, Amico J, Nelson RJ, Hennighausen L, Wagner KU. (1998). Targeted reduction of oxytocin expression provides insights into its physiological roles. Adv. Exp. Med. Biol., 449: 231-40.
Wojnowski L., Bernal R., Park C.M., Handel M.A., Hollander W.F., Zimmer A. (1998) Reduced activity of Braf protein kinase in hop and hop(hpy) mouse mutants. Mamm. Genome, 9: 905-906.
Wojnowski L, Stancato LF Zimmer AM, Beck TW, Larner AC, Rapp UR, Zimmer A. (1998). Craf-1 kinase is essentiell for mouse development. Mech. Dev., 76: 141-149.
Zimmer A, Zimmer AM, Baffi J, Reynolds K, Usdin T, Palkovits M, Mezey E. (1998). Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene. Proc. Natl. Acad. Sci. USA, 95: 2630-2635.
Inoue M, Tokuyama S, Shimohira I, Yoshida A, Kobayashi M, Kozaki S, Zimmer A, Ueda H. (1998). Nociceptin/orphanin FQ-induced nociceptive responses through substance P release from peripheral nerve endings in mice. Proc. Natl. Acad. Sci. USA, 95: 10949-10953.
Josephson R, Müller T, Pickel J, Okabe S, Reynolds K, Turner PA, Zimmer A, McKay RDG. (1998). POU transcription factors control expression of CNS stem cell specific genes. Development, 125: 3087-3100.
1997
Bhattacharyya N., Dey A., Minucci S., Zimmer A., John S., Hager G., Ozato K. (1997). Retinoid-induced chromatin structure alterations in the retinoic acid receptor beta 2 promoter. Mol. Cell Biol. 17:6481-6490.
Wojnowski L, Zimmer A. (1997). Use of transgenic mice to study the activation of retionic acid-responsive promoters. Meth. Enzymol, 282: 77-85.
Wojnowski L, Zimmer AM, Beck TW, Hahn H, Bernal R, Rapp UR, Zimmer A. (1997). Endothelial apoptosis in Braf-deficient mice. Nature Genetics, 16: 293-297.
Hahn H, Wojnowski L, Zimmer AM, Hall J, Miller G. Zimmer A. (1998). Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome. Nature Medicine, 4: 619-622.
1996
Hellmich HL, Kos L, Cho ES, Mahon KA, Zimmer A. (1996). Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions. Mech. Dev., 54: 95-105.
Robinson GW, Smith GS, Gallahan D, Zimmer A, Furth PA, Hennighausen L. (1996). Understanding mammary gland development through the imbalanced expression of growth regulators. Dev. Dyn., 206: 159-168.
Reynolds K, Zimmer AM, Zimmer A. (1996). Regulation of RAR beta 2 mRNA expression: Evidence for an inhibitory peptide encoded in the 5'-untranslated region. J Cell Biol., 134: 827-835.
König M, Zimmer AM, Steiner H, Holmes PV, Crawley JN, Brownstein MJ, Zimmer A. (1996). Pain responses, anxiety, and aggression in mice deficient in pre-proenkephalin. Nature, 383: 535-538.
Zimmer A. (1996). Gene targeting and behavior: a genetic problem requires a genetic solution. Trends Neurosci., 19: 470.
1995
Kurtz A, Zimmer A. (1995). The mouse homolog of the human Miller-Dieker chromosomal region (MDCR) maps to mouse chromosome-11 in close proximity to Mov9 and D11Nds1. Mamm. Genome, 6: 145-146.
Kurtz A, Zimmer A. (1995). Interspecies fluorescence in-situ hybridization further defines synteny homology between mouse Chromosome-11 and human Chromosome-17. Mamm. Genome, 379-380.
1994
Zimmer A, Zimmer A, Reynolds K. (1994). Gene targeting constructs: effects of vector topology on co-expression efficiency of positive and negative selectable marker genes. Biochem. Biophys. Res. Commun., 201: 943-949.
Zimmer A, Zimmer AM, Reynolds K. (1994). Tissue specific expression of the retinoic acid receptor-beta-2: Regulation by short open reading frames in the 5'-noncoding region. J. Cell Biol., 127: 1111-1119.
Kurtz A, Zimmer A, Schnütgen F, Brüning G, Spener F, Müller T. (1994). The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development. Development, 120: 2637-2649.
Eisel U, Reynolds K, Riddick M, Zimmer A, Zimmer A. (1994). Inhibition of Spermatogenesis by Tetanus Toxin Expression in Sertoli Cells of Transgenic Mice. In: Function of Somatic Cells in the Testis. (ed. A Bartke), pp 195-201. Springer-Verlag, New York.
1993
Eisel U, Reynolds K, Riddick M, Zimmer A, Niemann H, Zimmer A. (1993). Tetanus toxin light chain expression in Sertoli cells of transgenic mice causes alterations of the actin cytoskeleton and disrupts spermatogenesis. EMBO J, 12: 3365-72.
1992
Zimmer A, Zimmer A. (1992). Induction of a RAR beta 2-lacZ transgene by retinoic acid reflects the neuromeric organization of the central nervous system. Development, 116: 977-983.
Zimmer A. (1992). Manipulating the genome by homologous recombination in embryonic stem cells. Annu. Rev. Neurosci., 15: 115-37.
Zimmer A, Wang Z-Q, Wagner EF, Gruss P. (1992). Homologous recombination in embryonic stem cells as a means to generate mice with defined mutations. In: Mechanisms of Eucaryotic DNA Recombination. (ed. ME Gottesman, H Vogel), pp 29 - 40. Academic Press Inc., San Diego.
1991
Reynolds K, Mezey E, Zimmer A. (1991). Activity of the beta-retinoic acid receptor promoter in transgenic mice. Mech. Dev., 36: 15-29.
Zimmer A, Gruss P. (1991). Use of polymerase chain reaction (PCR) to detect homologous recombination in transfected cell lines. In: Gene Transfer and Expression Protocols. Vol. 7 (ed. EJ Murray), pp 411-417. The Humana Press Inc., Clifton, NJ.
1989
Zimmer A, Gruss P. (1989). Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination. Nature, 338: 150-3.
Zimmer A, Gruss P. (1989). New strategies in developmental biology: in vivo mutagenesis as a tool to dissect mammalian development. In: Vectors as Tools for the Study of Normal and Abnormal Growth and Differentiation. Vol. H 34 (ed. H Lother), pp 17-32. Springer Verlag, Berlin, Heidelberg.
Zimmer A, Gruss P. (1989). Precision mutagenesis by homologous recombination. In: Current Communications in Molecular Biology. Molecular Genetics of Early Drosophila and Mouse Development. (ed. M.R. Capecchi). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
1987
Schulze F, Chowdhury K, Zimmer A, Drescher U, Gruss P. (1987). The murine homeo box gene product, Hox 1.1 protein, is growth-controlled and associated with chromatin. Differentiation, 36: 130-137.
1986
Jost E, Lepper K, Högner D, Zimmer A, Boschek B. (1986). Redistribution of nuclear lamins in mitotic cells. Biol. Cell, 57: 111-126.