en

Prof. Dr. Rudi Balling

 Seniorprofessor

Many neurodegenerative diseases are linked to perturbations in energy metabolism.
Glycolysis, the pentose phosphate pathway and the TCA-cycle, coupled to the mitochondrial electron transport chain, are the core metabolic pathways, providing not only ATP and energy equivalents, such as NADH/NADPH, but also important precursors and substrates for biosynthetic reactions, including neurotransmitters.
Whereas by now most of the components are well known, their precise regulation in the context of temporally and spatially changing needs are less understood.
We are interested in the regulatory relationship between the TCA-cycle and coupled metabolic and signalling pathways. A particular interest is on the development of computational models for the process of anaplerosis, the filling up of the TCA-cycle, e.g. by intermediate metabolites or amino acids, such as glutamate, glutamine or GABA.
Our goal is to use these models to obtain insight into metabolic pathways that might be perturbed in neurodegenerative diseases and could be used for preventive or therapeutic interventions

University of Bonn

Institute of Molecular Psychiatry

Venusberg-Campus 1, Bldg. 76

53127 Bonn

Germany

CV

2022 - present Seniorprofessor

University of Bonn, Institute of Molecular Psychiatry, Germany

2009 - 2021 Director

Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Luxembourg

02/2018 - 08/2018 Visiting Scientist

Translational Research Institute (Host: Dr. Eric Topol), Scripps Research Institute, La Jolla, CA, USA

01/2009 - 07/2009 Visiting Scientist

Broad Institute (Host Dr. Eric Lander), MIT-Harvard, Boston, USA

2001 - 2019 Scientific Director of Helmholtz Center for Infection Research (HZI)

Braunschweig, Germany

1993 - 2000 Director

Institute of Mammalian Genetics, GSF-Research Center, Munich, Germany

1998 - 2000 Professor and Chair of Developmental Genetics

Technical University of Munich, Germany

1991 - 1993 Max Planck Junior Investigator

Max Planck Institute of Immunobiology, Freiburg, Germany

1987 - 1991 Staff Scientist

Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Göttingen

1985 - 1987 Postdoctoral Fellow

Samuel Lunenfeld Research Institute, Laboratory of Dr. Janet Rossant, Toronto, Canada

1981 - 1984 PhD-Student

Institute of Anatomy and Reproductive Biology, University of Aachen, Germany

1981 - 1982 DAAD-Scholar, NIEHS (NIH)

Laboratory of Reproductive and Developmental Toxicology Research Triangle Park, N.C., USA

1978 – 1979 Fulbright-Scholar and Graduate Student in Animal Nutrition (M.S.)

Dept. of Animal Sciences, Washington State University, Pullman, USA

1974 - 1980 Undergraduate Studies in Human Nutrition (Diploma)

University of Bonn, Germany

Ordre de Mérite du Grand-Duché de Luxembourg (Commandeur) (2016)
Guest Professor, National Institute of Genetics, Mishima, Japan (2007-2009)
Guest Professor, College of Life Science, Peking University, Beijing, China (2006-2009)
Member Braunschweiger Wissenschaftliche Gesellschaft, Germany (2008)
Member of the Berlin-Brandenburg Academy of Sciences, Germany (2001)
Honorary Member of American Association of Anatomists, USA (1999)
Honorary Member of Japanese Society of Inherited Metabolic Diseased, Japan (1999)
European Molecular Biology Organization, EMBO (1998)
Fulbright Scholarship, Washington State University, Pullman, USA, (1978-1979)

President of German Federation of Biological and Biomedical Societies (VBIO), (2007-2009)
President of 20. International Congress of Genetics, Berlin (2008)
President of German Society of Genetics (GfG) (2002 - 2005)
President of International Mammalian Genome Society (2003

Member of Scientific Advisory Boards (SAB´s)
Co-Editor "Annual Review of Nutrition", New York (since 2017)
SAB "Digital Life Norway", Norwegian Research Council (since 2017)
SAB, Center for Integrated Oncology, University of Köln (since 2016)
Board-Member (Kuratorium) Aventis Foundation, Frankfurt (since 2015)
SAB, Leibniz Institute for Aging Research (FLI), Jena (since 2014)
SAB, Institute of Molecular Genetics, Prague (since 2013)
SAB, RIKEN Centre for Integrative Medicine, Yokohama, (since 2014)

Megeno, SARL, Luxembourg (2015)
Theracule, SARL, Luxembourg (2013)
Ingenium Pharmaceuticals AG, Munich (1997)
Hexagen Ltd, Cambridge, UK (1996)

Awards

Friedrich Wilhelm Prize

Jahr:

1992

Friedrich Seidel Prize

Jahr:

1989

Latest Publications

Cardiovascular history and risk of idiopathic Parkinson’s disease: a cross-sectional observational study

Shubhra Acharya1,2, Andrew I. Lumley1, Yvan Devaux1* and NCER-PD Consortium 
July 2024

BMC Neuroscience 25(1)

Comprehensive blood metabolomics profiling of Parkinson’s disease reveals coordinated alterations in xanthine metabolism

Elisa Gómez de Lope 1, Rebecca Ting Jiin Loo1, Armin Rauschenberger 1, Muhammad Ali 1,Lukas Pavelka 2,3, Tainá M. Marques3, Clarissa P. C. Gomes4, Rejko Krüger 2,3,4 & Enrico Glaab1On behalf of the NCER-PD Consortium

March 2024
npj Parkinson s Disease 10(1)

The Warburg Effect Reinterpreted 100 yr on: A First-Principles Stoichiometric Analysis and Interpretation from the Perspective of ATP Metabolism in Cancer Cells

Sunil Nath, Rudi Balling

February 2024
Function 5(3)